Seroatlas · Human Serome Atlas

GALNT12

Polypeptide N-acetylgalactosaminyltransferase 12

Also known as: GalNAc-T12, GLT12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXK2
Gene
GALNT12
Ensembl
ENSG00000119514
Chromosome
9
Canonical length
581 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q8IXK2|GALNT12
     1  MWGRTARRRC PRELRRGREA LLVLLALLAL AGLGSVLRAQ RGAGAGAAEP GPPRTPRPGR
    61  REPVMPRPPV PANALGARGE AVRLQLQGEE LRLQEESVRL HQINIYLSDR ISLHRRLPER
   121  WNPLCKEKKY DYDNLPRTSV IIAFYNEAWS TLLRTVYSVL ETSPDILLEE VILVDDYSDR
   181  EHLKERLANE LSGLPKVRLI RANKREGLVR ARLLGASAAR GDVLTFLDCH CECHEGWLEP
   241  LLQRIHEEES AVVCPVIDVI DWNTFEYLGN SGEPQIGGFD WRLVFTWHTV PERERIRMQS
   301  PVDVIRSPTM AGGLFAVSKK YFEYLGSYDT GMEVWGGENL EFSFRIWQCG GVLETHPCSH
   361  VGHVFPKQAP YSRNKALANS VRAAEVWMDE FKELYYHRNP RARLEPFGDV TERKQLRDKL
   421  QCKDFKWFLE TVYPELHVPE DRPGFFGMLQ NKGLTDYCFD YNPPDENQIV GHQVILYLCH
   481  GMGQNQFFEY TSQKEIRYNT HQPEGCIAVE AGMDTLIMHL CEETAPENQK FILQEDGSLF
   541  HEQSKKCVQA ARKESSDSFV PLLRDCTNSD HQKWFFKERM L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNT12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 71 nTPM
  • rectum: 52 nTPM
  • colon: 52 nTPM
  • stomach: 52 nTPM
  • duodenum: 32 nTPM
  • small intestine: 26 nTPM

Single-cell type

  • goblet cells: 210 nCPM
  • mucous neck cells: 131 nCPM
  • foveolar cells: 122 nCPM
  • gastric chief cells: 104 nCPM
  • colonocytes: 100 nCPM
  • epididymal principal cells: 71 nCPM

Immune cell

  • MAIT T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.6 nTPM
  • NK-cell: 0.6 nTPM
  • eosinophil: 0.5 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • gdT-cell: 0.3 nTPM

Brain region

  • cerebellum: 13 nTPM
  • choroid plexus: 8.2 nTPM
  • pons: 4.9 nTPM
  • medulla oblongata: 3.5 nTPM
  • white matter: 2.5 nTPM
  • cerebral cortex: 2.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GALNT12.

Disease | AllUniProt

Conditions GALNT12 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNT12 as an antibody target. Whether an autoantibody or antibody against GALNT12 could matter depends on whether native GALNT12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNT12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNT12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GALNT12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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