Seroatlas · Human Serome Atlas

GALNT11

Polypeptide N-acetylgalactosaminyltransferase 11

Also known as: GalNAc-T11, GLT11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCW6
Gene
GALNT11
Ensembl
ENSG00000178234
Chromosome
7
Canonical length
608 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

Enables Notch binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

608 residues, UniProt reviewed canonical sequence.

>Q8NCW6|GALNT11
     1  MGSVTVRYFC YGCLFTSATW TVLLFVYFNF SEVTQPLKNV PVKGSGPHGP SPKKFYPRFT
    61  RGPSRVLEPQ FKANKIDDVI DSRVEDPEEG HLKFSSELGM IFNERDQELR DLGYQKHAFN
   121  MLISDRLGYH RDVPDTRNAA CKEKFYPPDL PAASVVICFY NEAFSALLRT VHSVIDRTPA
   181  HLLHEIILVD DDSDFDDLKG ELDEYVQKYL PGKIKVIRNT KREGLIRGRM IGAAHATGEV
   241  LVFLDSHCEV NVMWLQPLLA AIREDRHTVV CPVIDIISAD TLAYSSSPVV RGGFNWGLHF
   301  KWDLVPLSEL GRAEGATAPI KSPTMAGGLF AMNRQYFHEL GQYDSGMDIW GGENLEISFR
   361  IWMCGGKLFI IPCSRVGHIF RKRRPYGSPE GQDTMTHNSL RLAHVWLDEY KEQYFSLRPD
   421  LKTKSYGNIS ERVELRKKLG CKSFKWYLDN VYPEMQISGS HAKPQQPIFV NRGPKRPKVL
   481  QRGRLYHLQT NKCLVAQGRP SQKGGLVVLK ACDYSDPNQI WIYNEEHELV LNSLLCLDMS
   541  ETRSSDPPRL MKCHGSGGSQ QWTFGKNNRL YQVSVGQCLR AVDPLGQKGS VAMAICDGSS
   601  SQQWHLEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
800 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 800 nTPM
  • kidney: 214 nTPM
  • pancreas: 79 nTPM
  • parathyroid gland: 55 nTPM
  • placenta: 43 nTPM
  • cerebral cortex: 39 nTPM

Single-cell type

  • choroid plexus epithelial cells: 1,027 nCPM
  • retinal pigment epithelial cells: 443 nCPM
  • retinal bipolar cells: 236 nCPM
  • renal connecting tubule cells: 190 nCPM
  • cytotrophoblasts: 173 nCPM
  • brain inhibitory neurons: 170 nCPM

Immune cell

  • gdT-cell: 28 nTPM
  • MAIT T-cell: 28 nTPM
  • NK-cell: 26 nTPM
  • memory CD8 T-cell: 26 nTPM
  • non-classical monocyte: 21 nTPM
  • naive CD8 T-cell: 20 nTPM

Brain region

  • choroid plexus: 879 nTPM
  • hippocampal formation: 94 nTPM
  • cerebral cortex: 77 nTPM
  • thalamus: 75 nTPM
  • basal ganglia: 71 nTPM
  • white matter: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.9
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GALNT11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNT11 as an antibody target. Whether an autoantibody or antibody against GALNT11 could matter depends on whether native GALNT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GALNT11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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