Seroatlas · Human Serome Atlas

GALNT10

Polypeptide N-acetylgalactosaminyltransferase 10

Also known as: GalNAc-T10, GLT10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86SR1
Gene
GALNT10
Ensembl
ENSG00000164574
Chromosome
5
Canonical length
603 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>Q86SR1|GALNT10
     1  MRRKEKRLLQ AVALVLAALV LLPNVGLWAL YRERQPDGTP GGSGAAVAPA AGQGSHSRQK
    61  KTFFLGDGQK LKDWHDKEAI RRDAQRVGNG EQGRPYPMTD AERVDQAYRE NGFNIYVSDK
   121  ISLNRSLPDI RHPNCNSKRY LETLPNTSII IPFHNEGWSS LLRTVHSVLN RSPPELVAEI
   181  VLVDDFSDRE HLKKPLEDYM ALFPSVRILR TKKREGLIRT RMLGASVATG DVITFLDSHC
   241  EANVNWLPPL LDRIARNRKT IVCPMIDVID HDDFRYETQA GDAMRGAFDW EMYYKRIPIP
   301  PELQKADPSD PFESPVMAGG LFAVDRKWFW ELGGYDPGLE IWGGEQYEIS FKVWMCGGRM
   361  EDIPCSRVGH IYRKYVPYKV PAGVSLARNL KRVAEVWMDE YAEYIYQRRP EYRHLSAGDV
   421  AVQKKLRSSL NCKSFKWFMT KIAWDLPKFY PPVEPPAAAW GEIRNVGTGL CADTKHGALG
   481  SPLRLEGCVR GRGEAAWNNM QVFTFTWRED IRPGDPQHTK KFCFDAISHT SPVTLYDCHS
   541  MKGNQLWKYR KDKTLYHPVS GSCMDCSESD HRIFMNTCNP SSLTQQWLFE HTNSTVLEKF
   601  NRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GALNT10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 52 nTPM
  • choroid plexus: 42 nTPM
  • cervix: 23 nTPM
  • stomach: 21 nTPM
  • bone marrow: 18 nTPM
  • blood vessel: 16 nTPM

Single-cell type

  • pituicytes/fscs: 783 nCPM
  • choroid plexus epithelial cells: 381 nCPM
  • megakaryocyte-erythroid progenitors: 305 nCPM
  • erythrocyte progenitors: 303 nCPM
  • pituitary stem cells: 284 nCPM
  • granulosa cells: 271 nCPM

Immune cell

  • gdT-cell: 3.1 nTPM
  • MAIT T-cell: 2.8 nTPM
  • eosinophil: 2.4 nTPM
  • neutrophil: 2.4 nTPM
  • basophil: 2.1 nTPM
  • naive B-cell: 2.1 nTPM

Brain region

  • choroid plexus: 64 nTPM
  • medulla oblongata: 28 nTPM
  • basal ganglia: 24 nTPM
  • midbrain: 24 nTPM
  • thalamus: 24 nTPM
  • pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
1.53
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GALNT10 as an antibody target. Whether an autoantibody or antibody against GALNT10 could matter depends on whether native GALNT10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GALNT10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GALNT10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GALNT10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...