Seroatlas · Human Serome Atlas

GAGE4

G antigen 4

Also known as: GAGE4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DSO3
Gene: GAGE4
Canonical length: 117 aa

OverviewNCBI Gene

No narrative summary is available for GAGE4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P0DSO3|GAGE4
     1  MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
    61  DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAGE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAGE4 as an antibody target. Whether an autoantibody or antibody against GAGE4 could matter depends on whether native GAGE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAGE4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAGE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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