Seroatlas · Human Serome Atlas

GAGE2E

G antigen 2E

Also known as: GAG2E_HUMAN, GAGE8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4V326
Gene
GAGE2E
Ensembl
ENSG00000275113
Chromosome
X
Canonical length
110 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for GAGE2E in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

110 residues, UniProt reviewed canonical sequence.

>Q4V326|GAGE2E
     1  MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
    61  DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAGE2E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • testis: 52 nTPM
  • stomach: 15 nTPM
  • retina: 2.3 nTPM
  • ovary: 0.3 nTPM
  • salivary gland: 0.3 nTPM
  • spleen: 0.2 nTPM

Single-cell type

  • differentiating spermatogonia: 1.1 nCPM
  • early primary spermatocytes: 0.6 nCPM
  • undifferentiated spermatogonia: 0.2 nCPM
  • decidual stromal cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • T-reg: 3 nTPM
  • naive B-cell: 1 nTPM
  • naive CD4 T-cell: 1 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • basophil: 0.3 nTPM
  • neutrophil: 0.3 nTPM

Brain region

  • midbrain: 1.1 nTPM
  • basal ganglia: 0.6 nTPM
  • cerebral cortex: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM
  • white matter: 0.3 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAGE2E as an antibody target. Whether an autoantibody or antibody against GAGE2E could matter depends on whether native GAGE2E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAGE2E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAGE2E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAGE2E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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