Seroatlas · Human Serome Atlas

GAGE2D

G antigen 2D

Also known as: GGE2D_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UEU5
Gene: GAGE2D
Canonical length: 116 aa

OverviewNCBI Gene

No narrative summary is available for GAGE2D in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q9UEU5|GAGE2D
     1  MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED
    61  EGASAGQGPK PEADSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAGE2D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0.43
gnomAD missense Z: 0.15

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAGE2D as an antibody target. Whether an autoantibody or antibody against GAGE2D could matter depends on whether native GAGE2D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAGE2D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAGE2D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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