GAGE2A
G antigen 2A
Also known as: CT4.2, GAG2A_HUMAN, GAGE2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6NT46
- Gene
- GAGE2A
- Ensembl
- ENSG00000189064
- Chromosome
- X
- Canonical length
- 116 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Plasma membrane,Cytosol
OverviewNCBI Gene
No narrative summary is available for GAGE2A in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
116 residues, UniProt reviewed canonical sequence.
>Q6NT46|GAGE2A
1 MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGQD
61 EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN PEEVKTPEEG EKQSQCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GAGE2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 89 nTPM
Expression across tissuesHPA
Tissue
- testis: 89 nTPM
- retina: 0.7 nTPM
- ovary: 0.2 nTPM
- cerebral cortex: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- differentiating spermatogonia: 499 nCPM
- early primary spermatocytes: 214 nCPM
- undifferentiated spermatogonia: 146 nCPM
- oocytes: 4.6 nCPM
- late spermatids: 2 nCPM
- peritubular myoid cells: 1.6 nCPM
Immune cell
- memory B-cell: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 0.6 nTPM
- basal ganglia: 0.4 nTPM
- amygdala: 0.2 nTPM
- hippocampal formation: 0.2 nTPM
- hypothalamus: 0.2 nTPM
- medulla oblongata: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0.1
- gnomAD missense Z
- -0.79
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GAGE2A as an antibody target. Whether an autoantibody or antibody against GAGE2A could matter depends on whether native GAGE2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GAGE2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GAGE2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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