Seroatlas · Human Serome Atlas

GAGE12J

G antigen 12J

Also known as: GAGE11, GG12J_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NER3
Gene
GAGE12J
Ensembl
ENSG00000224659
Chromosome
X
Canonical length
117 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for GAGE12J in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A6NER3|GAGE12J
     1  MSWRGRSTYY WPRPRPYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
    61  DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAGE12J can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • testis: 22 nTPM
  • retina: 2.1 nTPM
  • epididymis: 0.6 nTPM
  • stomach: 0.2 nTPM
  • ovary: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • differentiating spermatogonia: 1.1 nCPM
  • lactotrophs: 0.2 nCPM
  • corticotrophs: 0.1 nCPM
  • early primary spermatocytes: 0.1 nCPM
  • gonadotrophs: 0.1 nCPM
  • undifferentiated spermatogonia: 0.1 nCPM

Immune cell

  • naive CD4 T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • medulla oblongata: 0.4 nTPM
  • midbrain: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
-1.18

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAGE12J as an antibody target. Whether an autoantibody or antibody against GAGE12J could matter depends on whether native GAGE12J is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAGE12J is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAGE12J as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAGE12J. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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