GAGE12G
G antigen 12G
Also known as: GG12G_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0CL81
- Gene
- GAGE12G
- Ensembl
- ENSG00000215269
- Chromosome
- X
- Canonical length
- 117 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Plasma membrane,Cytosol
OverviewNCBI Gene
No narrative summary is available for GAGE12G in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P0CL81|GAGE12G
1 MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
61 DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GAGE12G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 58 nTPM
Expression across tissuesHPA
Tissue
- testis: 58 nTPM
- stomach: 5.7 nTPM
- retina: 0.9 nTPM
- ovary: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- b-cells: 0 nCPM
Immune cell
- T-reg: 11 nTPM
- NK-cell: 7.1 nTPM
- memory CD4 T-cell: 6.8 nTPM
- intermediate monocyte: 6.1 nTPM
- plasmacytoid DC: 6.1 nTPM
- non-classical monocyte: 6 nTPM
Brain region
- cerebral cortex: 0.2 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GAGE12G as an antibody target. Whether an autoantibody or antibody against GAGE12G could matter depends on whether native GAGE12G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GAGE12G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GAGE12G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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