Seroatlas · Human Serome Atlas

GAGE10

G antigen 10

Also known as: GAG10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NGK3
Gene
GAGE10
Ensembl
ENSG00000215274
Chromosome
X
Canonical length
116 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for GAGE10 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>A6NGK3|GAGE10
     1  MSWRGRSTYR PRPRRYVEPP EMIGPMLPEQ FSDEVEPATP EEGEPATQRQ DPAAAQEGED
    61  EGASAGQGPK PEADSQEQVH PKTGCECGDG PDGQEMGLPN PEEVKRPEEG EKQSQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAGE10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
1.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.5 nTPM
  • pituitary gland: 0.7 nTPM
  • ovary: 0.5 nTPM
  • retina: 0.5 nTPM
  • basal ganglia: 0.4 nTPM
  • epididymis: 0.4 nTPM

Single-cell type

  • thyrotrophs: 16 nCPM
  • ependymal cells: 12 nCPM
  • lactotrophs: 11 nCPM
  • early primary spermatocytes: 9.9 nCPM
  • corticotrophs: 8.7 nCPM
  • gonadotrophs: 8.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 1.7 nTPM
  • midbrain: 1.3 nTPM
  • cerebral cortex: 1 nTPM
  • white matter: 1 nTPM
  • amygdala: 0.9 nTPM
  • hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0
gnomAD missense Z
-0.93

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAGE10 as an antibody target. Whether an autoantibody or antibody against GAGE10 could matter depends on whether native GAGE10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAGE10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAGE10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAGE10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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