GAGE1
G antigen 1
Also known as: CT4.1, GAGE1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DTW1
- Gene
- GAGE1
- Ensembl
- ENSG00000205777
- Chromosome
- X
- Canonical length
- 117 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Plasma membrane,Cytosol
OverviewNCBI Gene
This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P0DTW1|GAGE1
1 MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE
61 DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEGQSQCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GAGE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 1.7 nTPM
Expression across tissuesHPA
Tissue
- testis: 1.7 nTPM
- retina: 0.5 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- differentiating spermatogonia: 152 nCPM
- early primary spermatocytes: 54 nCPM
- undifferentiated spermatogonia: 47 nCPM
- late primary spermatocytes: 1.1 nCPM
- late spermatids: 1.1 nCPM
- retinal bipolar cells: 0.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hippocampal formation: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -1.57
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GAGE1 as an antibody target. Whether an autoantibody or antibody against GAGE1 could matter depends on whether native GAGE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GAGE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GAGE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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