GAFA1
Putative uncharacterized protein GAFA-1
Also known as: GAFA1_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for GAFA1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
74 residues, UniProt reviewed canonical sequence.
>Q96PS6|GAFA1
1 MIKHSWIHLY VMASAMSSSP IFFFFQRWSL TLSLRLECSS AIIKPTAASN SCVQVNLPPS
61 MCDYRHEPLC LAFLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GAFA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.61
OntologyGO
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GAFA1 as an antibody target. Whether an autoantibody or antibody against GAFA1 could matter depends on whether native GAFA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GAFA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GAFA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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