Seroatlas · Human Serome Atlas

GADL1

Acidic amino acid decarboxylase GADL1

Also known as: GADL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZQY3
Gene: GADL1
Ensembl: ENSG00000144644
Chromosome: 3
Canonical length: 521 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable carboxy-lyase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>Q6ZQY3|GADL1
     1  MSSDSDRQCP VDGDIDQQEM IPSKKNAVLV DGVVLNGPTT DAKAGEKFVE EACRLIMEEV
    61  VLKATDVNEK VCEWRPPEQL KQLLDLEMRD SGEPPHKLLE LCRDVIHYSV KTNHPRFFNQ
   121  LYAGLDYYSL VARFMTEALN PSVYTYEVSP VFLLVEEAVL KKMIEFIGWK EGDGIFNPGG
   181  SVSNMYAMNL ARYKYCPDIK EKGLSGSPRL ILFTSAECHY SMKKAASFLG IGTENVCFVE
   241  TDGRGKMIPE ELEKQVWQAR KEGAAPFLVC ATSGTTVLGA FDPLDEIADI CERHSLWLHV
   301  DASWGGSALM SRKHRKLLHG IHRADSVAWN PHKMLMAGIQ CCALLVKDKS DLLKKCYSAK
   361  ASYLFQQDKF YDVSYDTGDK SIQCSRRPDA FKFWMTWKAL GTLGLEERVN RALALSRYLV
   421  DEIKKREGFK LLMEPEYANI CFWYIPPSLR EMEEGPEFWA KLNLVAPAIK ERMMKKGSLM
   481  LGYQPHRGKV NFFRQVVISP QVSREDMDFL LDEIDLLGKD M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GADL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 25 nTPM
tongue: 11 nTPM
retina: 1.4 nTPM
bone marrow: 1.1 nTPM
thyroid gland: 0.8 nTPM
kidney: 0.7 nTPM

Single-cell type

myonuclei: 152 nCPM
mesothelial cells: 36 nCPM
epicardial cells: 32 nCPM
oocytes: 23 nCPM
thymic myoid cells: 16 nCPM
somatotrophs: 15 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebellum: 20 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 19 nTPM
white matter: 18 nTPM
amygdala: 18 nTPM
hippocampal formation: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.72
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

carboxylic acid metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GADL1 as an antibody target. Whether an autoantibody or antibody against GADL1 could matter depends on whether native GADL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GADL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GADL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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