Seroatlas · Human Serome Atlas

GAB4

GRB2-associated-binding protein 4

Also known as: GAB4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2WGN9
Gene: GAB4
Ensembl: ENSG00000215568
Chromosome: 22
Canonical length: 574 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>Q2WGN9|GAB4
     1  MSLPSPSPSR ELCPPDPAFA PLSSWPGSGP AGGSTRSGHV LYSGWLRKSP PEKKLRLFAW
    61  RKRWFILRRG QTSSDPDVLE YYKNDGSKKP LRTINLNLCE QLDVDVTLNF NKKEIQKGYM
   121  FDIKTSERTF YLVAETREDM NEWVQSICQI CGFRQEESTG FLGNISSASH GLCSSPAEPS
   181  CSHQHLPQEQ EPTSEPPVSH CVPPTWPIPA PPGCLRSHQH ASQRAEHARS ASFSQGSEAP
   241  FIMRRNTAMQ NLAQHSGYSV DGVSGHIHGF HSLSKPSQHN AEFRGSTHRI PWSLASHGHT
   301  RGSLTGSEAD NEASSGKYTQ HGGGNASRPA ESMHEGVCSF LPGRTLVGLS DSIASEGSCV
   361  PMNPGSPTLP AVKQAGDDSQ GVCIPVGSCL VRFDLLGSPL TELSMHQDLS QGHEVQLPPV
   421  NRSLKPNQKA NPTPPNLRNN RVINELSFKP PVTEPWSGTS HTFDSSSSQH PISTQSITNT
   481  DSEDSGERYL FPNPASAFPV SGGTSSSAPP RSTGNIHYAA LDFQPSKPSI GSVTSGKKVD
   541  YVQVDLEKTQ ALQKTMHEQM CLRQSSEPPR GAKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 1.9 nTPM

Expression across tissuesHPA

Tissue

testis: 1.9 nTPM
spinal cord: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 43 nCPM
late primary spermatocytes: 11 nCPM
early spermatids: 9.2 nCPM
early primary spermatocytes: 3.8 nCPM
differentiating spermatogonia: 1.8 nCPM
undifferentiated spermatogonia: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.6 nTPM
medulla oblongata: 0.3 nTPM
midbrain: 0.3 nTPM
spinal cord: 0.3 nTPM
pons: 0.2 nTPM
thalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.96
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAB4 as an antibody target. Whether an autoantibody or antibody against GAB4 could matter depends on whether native GAB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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