Seroatlas · Human Serome Atlas

GAB3

GRB2-associated-binding protein 3

Also known as: GAB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WWW8
Gene
GAB3
Ensembl
ENSG00000160219
Chromosome
X
Canonical length
586 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q8WWW8|GAB3
     1  MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN KHSSKPIRVI
    61  DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK TEQEMQVWVH SISQVCNLGH
   121  LEDGADSMES LSYTPSSLQP SSASSLLTAH AASSSLPRDD PNTNAVATEE TRSESELLFL
   181  PDYLVLSNCE TGRLHHTSLP TRCDSWSNSD RSLEQASFDD VFVDCLQPLP SSHLVHPSCH
   241  GSGAQEVPSS RPQAALIWSR EINGPPRDHL SSSPLLESSL SSTIQVDKNQ GSLPCGAKEL
   301  DIMSNTPPPR PPKPSHLSER RQEEWSTHSG SKKPECTLVP RRISLSGLDN MRTWKADVEG
   361  QSLRHRDKRL SLNLPCRFSP MYPTASASIE DSYVPMSPQA GASGLGPHCS PDDYIPMNSG
   421  SISSPLPELP ANLEPPPVNR DLKPQRKSRP PPLDLRNLSI IREHASLTRT RTVPCSRTSF
   481  LSPERNGINS ARFFANPVSR EDEESYIEME EHRTASSLSS GALTWTKKFS LDYLALDFNS
   541  ASPAPMQQKL LLSEEQRVDY VQVDEQKTQA LQSTKQEWTD ERQSKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 13 nTPM
  • bone marrow: 12 nTPM
  • heart muscle: 7 nTPM
  • lymph node: 7 nTPM
  • appendix: 6.5 nTPM
  • tonsil: 6.2 nTPM

Single-cell type

  • megakaryocyte progenitors: 218 nCPM
  • cardiomyocytes: 204 nCPM
  • microglia: 158 nCPM
  • erythrocyte progenitors: 129 nCPM
  • megakaryocyte-erythroid progenitors: 127 nCPM
  • sertoli cells: 111 nCPM

Immune cell

  • basophil: 26 nTPM
  • gdT-cell: 13 nTPM
  • MAIT T-cell: 10 nTPM
  • memory CD8 T-cell: 9.7 nTPM
  • neutrophil: 8.9 nTPM
  • eosinophil: 8.7 nTPM

Brain region

  • white matter: 31 nTPM
  • medulla oblongata: 25 nTPM
  • pons: 24 nTPM
  • cerebral cortex: 24 nTPM
  • basal ganglia: 21 nTPM
  • thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.95
gnomAD missense Z
1.47
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • SHP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAB3 as an antibody target. Whether an autoantibody or antibody against GAB3 could matter depends on whether native GAB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAB3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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