Seroatlas · Human Serome Atlas

G0S2

G0/G1 switch protein 2

Also known as: G0S2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P27469
Gene: G0S2
Ensembl: ENSG00000123689
Chromosome: 1
Canonical length: 103 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in extrinsic apoptotic signaling pathway and positive regulation of extrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>P27469|G0S2
     1  METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE
    61  AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ HAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against G0S2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1,271 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 1,271 nTPM
adipose tissue: 755 nTPM
liver: 622 nTPM
skeletal muscle: 611 nTPM
breast: 492 nTPM
lung: 338 nTPM

Single-cell type

neutrophils: 8,173 nCPM
breast lactating cells: 3,431 nCPM
cdc: 1,752 nCPM
pancreatic acinar cells: 1,619 nCPM
monocytes: 1,503 nCPM
epididymal efferent duct absorptive cells: 681 nCPM

Immune cell

neutrophil: 552 nTPM
eosinophil: 9.1 nTPM
memory CD4 T-cell: 2.5 nTPM
intermediate monocyte: 1.1 nTPM
classical monocyte: 1 nTPM
MAIT T-cell: 0.4 nTPM

Brain region

cerebral cortex: 80 nTPM
white matter: 12 nTPM
pons: 11 nTPM
hippocampal formation: 11 nTPM
midbrain: 10 nTPM
choroid plexus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.38
gnomAD missense Z: 0.3
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

G0/G1 switch protein 2
G0/G1 switch protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of G0S2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads G0S2 as an antibody target. Whether an autoantibody or antibody against G0S2 could matter depends on whether native G0S2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

G0S2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label G0S2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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