Seroatlas · Human Serome Atlas

FUT2

Galactoside alpha-(1,2)-fucosyltransferase 2

Also known as: FUT2_HUMAN, SE, Se2, SEC2, sej

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q10981
Gene: FUT2
Ensembl: ENSG00000176920
Chromosome: 19
Canonical length: 343 aa
Protein class: Blood group antigen proteins, Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway. It is also involved in cell-cell interaction, cell surface expression, and cell proliferation. Mutations in this gene are a cause of the H-Bombay blood group where red blood cells lack the H antigen. [provided by RefSeq, May 2022]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q10981|FUT2
     1  MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS TSKALGPSQL
    61  RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH STLAPIFRIT LPVLHSATAS
   121  RIPWQNYHLN DWMEEEYRHI PGEYVRFTGY PCSWTFYHHL RQEILQEFTL HDHVREEAQK
   181  FLRGLQVNGS RPGTFVGVHV RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV
   241  VTSNGMAWCR ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG
   301  GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 58 nTPM
duodenum: 42 nTPM
stomach: 27 nTPM
colon: 22 nTPM
esophagus: 22 nTPM
small intestine: 21 nTPM

Single-cell type

conjunctival goblet cells: 308 nCPM
salivary duct cells: 257 nCPM
enterocytes: 213 nCPM
esophageal apical cells: 192 nCPM
salivary ionocytes: 172 nCPM
respiratory secretory cells: 122 nCPM

Immune cell

basophil: 0.9 nTPM
T-reg: 0.6 nTPM
memory CD4 T-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
neutrophil: 0.4 nTPM

Brain region

cerebellum: 20 nTPM
cerebral cortex: 12 nTPM
hippocampal formation: 11 nTPM
basal ganglia: 11 nTPM
amygdala: 11 nTPM
white matter: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT2 as an antibody target. Whether an autoantibody or antibody against FUT2 could matter depends on whether native FUT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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