Seroatlas · Human Serome Atlas

FUT1

Galactoside alpha-(1,2)-fucosyltransferase 1

Also known as: FUT1_HUMAN, H, HSC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P19526
Gene
FUT1
Ensembl
ENSG00000174951
Chromosome
19
Canonical length
365 aa
Protein class
Blood group antigen proteins, Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>P19526|FUT1
     1  MWLRSHRQLC LAFLLVCVLS VIFFLHIHQD SFPHGLGLSI LCPDRRLVTP PVAIFCLPGT
    61  AMGPNASSSC PQHPASLSGT WTVYPNGRFG NQMGQYATLL ALAQLNGRRA FILPAMHAAL
   121  APVFRITLPV LAPEVDSRTP WRELQLHDWM SEEYADLRDP FLKLSGFPCS WTFFHHLREQ
   181  IRREFTLHDH LREEAQSVLG QLRLGRTGDR PRTFVGVHVR RGDYLQVMPQ RWKGVVGDSA
   241  YLRQAMDWFR ARHEAPVFVV TSNGMEWCKE NIDTSQGDVT FAGDGQEATP WKDFALLTQC
   301  NHTIMTIGTF GFWAAYLAGG DTVYLANFTL PDSEFLKIFK PEAAFLPEWV GINADLSPLW
   361  TLAKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 32 nTPM
  • stomach: 16 nTPM
  • lung: 12 nTPM
  • spleen: 6.2 nTPM
  • cerebellum: 5.9 nTPM
  • heart muscle: 4.6 nTPM

Single-cell type

  • parietal cells: 51 nCPM
  • mucous neck cells: 26 nCPM
  • pancreatic acinar cells: 26 nCPM
  • erythrocyte progenitors: 18 nCPM
  • cdc: 14 nCPM
  • platelets: 13 nCPM

Immune cell

  • basophil: 1.3 nTPM
  • neutrophil: 0.4 nTPM
  • NK-cell: 0.3 nTPM
  • memory B-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM

Brain region

  • cerebellum: 12 nTPM
  • cerebral cortex: 8.4 nTPM
  • basal ganglia: 8.2 nTPM
  • amygdala: 5.5 nTPM
  • hypothalamus: 5.5 nTPM
  • white matter: 4.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FUT1.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 63 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Para-Bombay phenotype
  • Bombay phenotype
  • BOMBAY PHENOTYPE, DIGENIC
  • FUT1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUT1 as an antibody target. Whether an autoantibody or antibody against FUT1 could matter depends on whether native FUT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FUT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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