FUOM

Protein identityUniProt · HPA

UniProt accession

A2VDF0

Gene

FUOM

Ensembl

ENSG00000148803

Chromosome

10

Canonical length

154 aa

Protein class

Enzymes, Predicted intracellular proteins

Quaternary structure

Homodecamer

OverviewNCBI Gene

Predicted to enable L-fucose mutarotase activity and fucose binding activity. Predicted to be involved in GDP-L-fucose salvage; fucose metabolic process; and fucosylation. Predicted to act upstream of or within female mating behavior and negative regulation of neuron differentiation. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>A2VDF0|FUOM
     1  MVALKGVPAL LSPELLYALA RMGHGDEIVL ADLNFPASSI CQCGPMEIRA DGLGIPQLLE
    61  AVLKLLPLDT YVESPAAVME LVPSDKERGL QTPVWTEYES ILRRAGCVRA LAKIERFEFY
   121  ERAKKAFAVV ATGETALYGN LILRKGVLAL NPLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUOM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

233 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.63

gnomAD pLI

0

gnomAD missense Z

-0.24

DepMap mean gene effect

0.15

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fucose metabolic process
• GDP-L-fucose salvage
• negative regulation of neuron differentiation
• neuron differentiation
• female mating behavior

Molecular functions

• fucose binding
• racemase and epimerase activity, acting on carbohydrates and derivatives
• L-fucose mutarotase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• D-ribose pyranase RbsD/L-fucose mutarotase FucU
• RbsD-like superfamily
• RbsD/FucU L-fucose mutarotase
• RbsD / FucU transport protein family

KeywordsUniProt

• Isomerase