Seroatlas · Human Serome Atlas

FUNDC2

FUN14 domain-containing protein 2

Also known as: DC44, FUND2_HUMAN, HCBP6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWH2
Gene: FUNDC2
Ensembl: ENSG00000165775
Chromosome: X
Canonical length: 189 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in intracellular triglyceride homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q9BWH2|FUNDC2
     1  METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN FESLDLAEFA
    61  KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI FQKVGKLAAT AVGGGFFLLQ
   121  LANHTGYIKV DWQRVEKDMK KAKEQLKIRK SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF
   181  GGFLLGMAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUNDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

tongue: 18 nTPM
skeletal muscle: 17 nTPM
heart muscle: 9.7 nTPM
pancreas: 7.3 nTPM
ovary: 5.7 nTPM
choroid plexus: 5.3 nTPM

Single-cell type

late spermatids: 2,447 nCPM
early spermatids: 345 nCPM
pancreatic acinar cells: 281 nCPM
parietal cells: 210 nCPM
decidual stromal cells: 161 nCPM
mast cells: 131 nCPM

Immune cell

total PBMC: 3.3 nTPM
non-classical monocyte: 2.9 nTPM
myeloid DC: 2.7 nTPM
naive CD8 T-cell: 2.6 nTPM
T-reg: 2.6 nTPM
gdT-cell: 2.5 nTPM

Brain region

cerebellum: 6 nTPM
pons: 5.3 nTPM
medulla oblongata: 5.1 nTPM
thalamus: 5.1 nTPM
choroid plexus: 4.9 nTPM
spinal cord: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.06
gnomAD missense Z: 0.36
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

5-trisphosphate binding
phosphatidylinositol-3
4

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FUNDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CYB5R3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUNDC2 as an antibody target. Whether an autoantibody or antibody against FUNDC2 could matter depends on whether native FUNDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUNDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUNDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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