Seroatlas · Human Serome Atlas

FUNDC1

FUN14 domain-containing protein 1

Also known as: FUND1_HUMAN, MGC51029

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVP5
Gene: FUNDC1
Ensembl: ENSG00000069509
Chromosome: X
Canonical length: 155 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>Q8IVP5|FUNDC1
     1  MATRNPPPQD YESDDDSYEV LDLTEYARRH QWWNRVFGHS SGPMVEKYSV ATQIVMGGVT
    61  GWCAGFLFQK VGKLAATAVG GGFLLLQIAS HSGYVQIDWK RVEKDVNKAK RQIKKRANKA
   121  APEINNLIEE ATEFIKQNIV ISSGFVGGFL LGLAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUNDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 46 nTPM
cerebral cortex: 38 nTPM
basal ganglia: 37 nTPM
midbrain: 36 nTPM
hypothalamus: 36 nTPM
heart muscle: 35 nTPM

Single-cell type

parietal cells: 193 nCPM
oocytes: 115 nCPM
megakaryocytes: 111 nCPM
granulosa cells: 64 nCPM
gastric chief cells: 61 nCPM
esophageal apical cells: 58 nCPM

Immune cell

plasmacytoid DC: 24 nTPM
myeloid DC: 12 nTPM
memory CD8 T-cell: 12 nTPM
naive CD4 T-cell: 12 nTPM
NK-cell: 12 nTPM
eosinophil: 11 nTPM

Brain region

medulla oblongata: 32 nTPM
cerebellum: 32 nTPM
pons: 29 nTPM
hypothalamus: 28 nTPM
thalamus: 26 nTPM
cerebral cortex: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.04
gnomAD missense Z: 0.26
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FUNDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUNDC1 as an antibody target. Whether an autoantibody or antibody against FUNDC1 could matter depends on whether native FUNDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUNDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUNDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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