FTMT
Ferritin, mitochondrial
Also known as: FTMT_HUMAN, MtF
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N4E7
- Gene
- FTMT
- Ensembl
- ENSG00000181867
- Chromosome
- 5
- Canonical length
- 242 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Enables ferroxidase activity and iron ion binding activity. Involved in several processes, including intracellular iron ion homeostasis; positive regulation of aconitate hydratase activity; and positive regulation of succinate dehydrogenase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
242 residues, UniProt reviewed canonical sequence.
>Q8N4E7|FTMT
1 MLSCFRLLSR HISPSLASLR PVRCCFALPL RWAPGRPLDP RQIAPRRPLA AAASSRDPTG
61 PAAGPSRVRQ NFHPDSEAAI NRQINLELYA SYVYLSMAYY FSRDDVALNN FSRYFLHQSR
121 EETEHAEKLM RLQNQRGGRI RLQDIKKPEQ DDWESGLHAM ECALLLEKNV NQSLLELHAL
181 ASDKGDPHLC DFLETYYLNE QVKSIKELGD HVHNLVKMGA PDAGLAEYLF DTHTLGNENK
241 QNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FTMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 49 nTPM
Expression across tissuesHPA
Tissue
- testis: 49 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- early spermatids: 822 nCPM
- late primary spermatocytes: 490 nCPM
- late spermatids: 119 nCPM
- leydig cells: 2.4 nCPM
- peritubular myoid cells: 1.9 nCPM
- breast secretory cells: 1.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.46
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.04
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FTMT as an antibody target. Whether an autoantibody or antibody against FTMT could matter depends on whether native FTMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FTMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FTMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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