Seroatlas · Human Serome Atlas

FTHL17

Ferritin heavy polypeptide-like 17

Also known as: CT38, FHL17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXU8
Gene: FTHL17
Ensembl: ENSG00000132446
Chromosome: X
Canonical length: 183 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a ferritin heavy chain-like protein. This gene is primarily expressed in embryonic germ cells. The encoded protein may lack ferroxidase activity. Multiple pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9BXU8|FTHL17
     1  MATAQPSQVR QKYDTNCDAA INSHITLELY TSYLYLSMAF YFNRDDVALE NFFRYFLRLS
    61  DDKMEHAQKL MRLQNLRGGH ICLHDIRKPE CQGWESGLVA MESAFHLEKN VNQSLLDLYQ
   121  LAVEKGDPQL CHFLESHYLH EQVKTIKELG GYVSNLRKIC SPEAGLAEYL FDKLTLGGRV
   181  KET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FTHL17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

testis: 3.8 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early primary spermatocytes: 17 nCPM
late primary spermatocytes: 2.8 nCPM
late spermatids: 1 nCPM
differentiating spermatogonia: 0.5 nCPM
undifferentiated spermatogonia: 0.4 nCPM
early spermatids: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.76
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FTHL17 as an antibody target. Whether an autoantibody or antibody against FTHL17 could matter depends on whether native FTHL17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FTHL17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FTHL17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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