Seroatlas · Human Serome Atlas

FTCDNL1

Formiminotransferase N-terminal subdomain-containing protein

Also known as: FONG, FONG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E5RQL4
Gene
FTCDNL1
Ensembl
ENSG00000226124
Chromosome
2
Canonical length
147 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable folic acid binding activity and transferase activity. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>E5RQL4|FTCDNL1
     1  MSSSRVGLRL AACLLNVSEA GRKYIVENIA KAALLDKNGK KHPQVSVLNI FSDQDYKRSV
    61  ITIATSVDKL GLAEDLVLHV PGCSVFLFGE ADLPEKRSLV QRRKQLGWFT RRDFSALQPD
   121  LGAAPSQRCG LTGSEHGFCF ALFFFFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FTCDNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
8.5 nTPM

Expression across tissuesHPA

Tissue

  • liver: 8.5 nTPM
  • skeletal muscle: 6.9 nTPM
  • tongue: 6.9 nTPM
  • spinal cord: 4.9 nTPM
  • thyroid gland: 4.7 nTPM
  • adrenal gland: 4.3 nTPM

Single-cell type

  • myonuclei: 145 nCPM
  • oligodendrocytes: 131 nCPM
  • bergmann glia: 128 nCPM
  • adrenal cortex cells: 110 nCPM
  • ependymal cells: 106 nCPM
  • choroid plexus epithelial cells: 90 nCPM

Immune cell

  • plasmacytoid DC: 7.5 nTPM
  • myeloid DC: 5.5 nTPM
  • intermediate monocyte: 5.2 nTPM
  • non-classical monocyte: 4.7 nTPM
  • classical monocyte: 3.8 nTPM
  • memory B-cell: 3.4 nTPM

Brain region

  • basal ganglia: 23 nTPM
  • white matter: 23 nTPM
  • midbrain: 21 nTPM
  • thalamus: 21 nTPM
  • medulla oblongata: 20 nTPM
  • spinal cord: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.41
gnomAD missense Z
1.23

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FTCDNL1 as an antibody target. Whether an autoantibody or antibody against FTCDNL1 could matter depends on whether native FTCDNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FTCDNL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FTCDNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FTCDNL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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