Seroatlas · Human Serome Atlas

FSIP2

Fibrous sheath-interacting protein 2

Also known as: FLJ34780, FSIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5CZC0
Gene: FSIP2
Ensembl: ENSG00000188738
Chromosome: 2
Canonical length: 6907 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body,Mid piece

OverviewNCBI Gene

This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

6907 residues, UniProt reviewed canonical sequence.

>Q5CZC0|FSIP2
     1  MELYLGACSK PAKVAVTKTV ASVLAADTQQ CRDGVHKTHF AGVGPAQLLD LPLGVKLPVI
    61  PGSNAVFYTT NFGEKLFRPS YGFNLTDPYC RLLENQYKSL HDPHLKAYYK RKDILKRLKK
   121  GGYITSNNKV VCTLRELNKY RQYLTSLKLD FERNYIKEQR ILAKQLHNIP ENNQIPQHCD
   181  VAQVQNWLLK EGTESIKDQE RLMRHRYLDM ISRKLEQLER TAEEQRLFLM DREERRQREH
   241  TRRKLTLRRK IEEEWKTKEM LLLTRMAEDV KREERIEEQQ HRNREESDRK KQDLLEKKMA
   301  YHLQKMQDTG FNGEDIGKNT FKYRGQDGTH ASPKNKKKTS EDIMLVYPAG DQNTYKETHG
   361  HTANAAHQRQ NSSNNFTKKN SASVVYQADV QDNGINQKRD GMVSKNSSIF DDRGGINISG
   421  QGSIISAQVS PTRNFSRVSQ AFLDPSKEEK ETNADWDGRP TKRSSYLCES GPQAHATDPG
   481  IFSSPVYTNM QQNLLQNCLQ EKVTSEELNI IIQNVMTWVV ATVTSILYPA ITKYEKRLQN
   541  NTYPVSDDSI LSSDSSSFCS TCSEDFTYRS YTSATTKTFQ AEPCAFVVDT SVRRPTTPIK
   601  PPPAHVEKTV VGKTCHIKGQ SIISKHKYNK TNLLYSYPKL RSCKSDSHLL ASFETGTKKS
   661  KDATTETDSL GSSLHCDKTA KAMDEMKNLK NVFVNFKCYL KGETEVILES ILREIMSDLT
   721  QAIPSLSSVT AEVFVEQCER EKEILLSNAH IPSVASEIVE NMLEKLESAV EKKCVEMFSQ
   781  DLSVDIKPSL AASDELLTSS NGKPLKNSMP HTLDPMCDIA EDMVHAILEK LMTLVSFKQN
   841  EFLHLKDTNK LSCQQHKTDP ICMFLQRAGK NKSSLESDEA SLIVNEEVQN LISNIFSQSS
   901  LVAYIEEAIN AILGYIQTEL NNERIIASEE TVVLLQLLED ILFQLHQEPV NESFQKSRQP
   961  RISSPSDTKE KYRLTGTRLS NSPRSGRPFP PINVPGMVLY SDDENEEIDN IVKNVLDSTF
  1021  KDEKVKSQEQ IPNHWFTKGN TCFECKRNIK PPTKPGSRSK AAFHDWELKT EPPSTNHEDI
  1081  LKKKLSSNKD ISTFSQDQKH QIEKASENIV TSILKEMLKD ISSVPFGHLD SKTGSEASVL
  1141  VSEKPQGLSH QEWIDQMFSV SEISTVAQEI TDSVLNILHK ASNYISNTTK SSISSSVHQI
  1201  SLHNSDTEHI VKEAPNKYPL KTWFDSEKKM KYLSLFDVDP EKPPWLKSGK SEPKPVDDIN
  1261  DKIIRTIFKR LKSFICPKLH MGFKSSLRSQ LSKYTAKIVN IVLCAIQNEL ELHKENLNLR
  1321  EIDHTKSLTD KGFFANTDKK LESLVTSIDD DILASPLLTC IYDMLLSSEN AHQRSISLSS
  1381  RKPKSATDSV DVQSILPNRQ DKKSFHKYLA TPCTHHSVNG GNHIKENAKL QVLERIGETL
  1441  HEMLSKLLGT HLHSQLSCSQ QSREMTNKNQ KMAAALQSNI QLISKAILDY ILAKLCGVDM
  1501  DTSFASCGLK AISESLDIDN PSFASIIEKM AKSTKIISSI VSRRVQEDNK EETKSKAKPV
  1561  APVSSKTPST KEMHPNKLKA VASDILNMVF AKLEGFANGH LEILGAINDG NKKSNKIGWE
  1621  YESTNISRDT HEASFLSALY MHAKKVSSAI LKVIQTELNV TSSDLKTSVE NPPPETQILK
  1681  YVVKLILDAV SSDMFNEMES EGGGIETYRY RPTYGSLPGG AESDSFLEDD AYTAKKIIDE
  1741  RSPQREEVKT RSLKQWALEK TLNKIEVKLK EPHISPIAPI IRNILNEIFQ STLINQLNVL
  1801  SLSHSNFNGM PHNVDEPTPQ TSVQFMDKMM DPLLSEADIT IVTDNIVRTV FHKLYSAAMT
  1861  ERNVRENRYK TITFSANVSS HEHTYKGKSS VTALDENPCT FQSRFSVADK ETKVNLAEDI
  1921  VQAILTNLET FATSKVKSLF YSQVNFTVPV ALPIQQDHST LSKALSAKDS YSDEQFSCCS
  1981  VDHTKSGKTN LCQLSLSKLN TYALQVARRN LQGIKQELDK ERENPFLTHD IGISESIASQ
  2041  IVNALLDIIS RKGKCDKNSS DKEIDLDQQK GVIEKLLNET KYRKVLQLQI QDTIEGILCD
  2101  IYEKTLFQNN LSFATPTLKC SIADKHSEEN SEMFMEGANK IIPKLSVPKS DVILISNDIV
  2161  NIVLHNLSSA ATLVINAKNP TSARLPLTFC DTFPKIDCQQ PLKGSKTERK TERFSYSRNQ
  2221  KSAYADDNQI TVVEKEDTQK SATDSCEENA NFITKTIFKR LESFATERID SLITLAFQSK
  2281  EKSFVIPELE NCKQNDSIFY DSSQVESDVN VLKISATETI LSQELTDFTF VGRREKLGST
  2341  IHLSQARLKT YADVIASAIL KLIKNDLDLE IQKIYPYQNN ILFQENIIVS EIVDSMLKML
  2401  DDKRSVKEIC FNSKENSNFS QLALSNEILL GHKEKERSTK QSLFTKYPLE QNQMILENKR
  2461  QIIVLEEIFM RNGESKNKEK GELLIAVEEL LNKLYQRVRE VTGHLPPLNE TANFISNSKI
  2521  KTSDTTQKNS FQSHINSVAN DIVESVLGKM YLVVVTSLYE NNKSRTEVEI SDHNDSLLMK
  2581  PLRFRETKQA GKISNSPRYA ISQAYSYVDS QNISVMENTL LPYLPLQVKK DLIQMVLNKI
  2641  TNFVSLPLKV SPKDNPKPCF KAHLKTRSKI TTLPKFTKKT HLGLSAAKAK SKTKLGPGEK
  2701  TLKDSRSKTA IGLSHIMSAG DAKNLLDTKL PTSELKIYAK DIIINILETI VKEFGKVKQT
  2761  KALPSDQIIA AGKIVNTVLQ ELYVTNNCNL AYPMKSSHLR LSQGNIGTGS LPKQQACFYL
  2821  ENVSSQLEHI FPREGIFKKL FDKWQTESND KENEKCKLLM IAENVLTEIS IKAKELEYSL
  2881  SLLNLPPLEN CESRFYNHFK GASTRAEDTK AQINMFGREI VEMLLEKLQL CFLSQIPTPD
  2941  SEETLSNSKE HITAKSKYGF PNKHSLSSLP IYNTKTKDQI SVGSSNQIVQ EIVETVLNML
  3001  ESFVDLQFKH ISKYEFSEIV KMPIENLSSI QQKLLNKKML PKLQPLKMFS DKSESNTINF
  3061  KENIQNILLR VHSFHSQLLT YAVNIISDML AVIKNKLDNE ISQMEPSSIS ILKENIVASE
  3121  IIGTLMDQCT YFNESLIQNL SRESLFQGAE NAYTVNQVEL ATNMKMFTSK LKEGSLGINP
  3181  SQVSKTGFVF CSDEDMKEKY RVSSDLPTSV RSSVEDTVKN SEPTKRPDSE TMPSCSTRNK
  3241  VQDHRPRESN FGSFDQTMKG NSYLPEGSFL QKLLRKASDS TEAALKQVLS FIEMGKGENL
  3301  RVFHYENLKP VVEPNQIQTT ISPLKICLAA ENIVNTVLSS CGFPSQPHTN ENREIMKPFF
  3361  ISKQSSLSEV SGGQKDNEKS LLRMQDKKIN YIPEEENENL EASREDSSFL QKLKKKEYPK
  3421  IETVKEVEAF TFADHEMGSN EVHLIARHVT TSVVTYLKNF ETTVFSEEKM SVSTWSRKKY
  3481  ESKQFLRNIY DDSSIYQCCE HLTESVLYHL TSSISDGTKK GREKEKAWEI QEATFSKIIS
  3541  IHSQVFESRS ISIGELALCI SEIIIKILFN NKIIQADIAQ KMVAIPTKYT YCPGIVSGGF
  3601  DDLFQDLLVG VIHVLSKEIE VDYHFESNVR NKSFSMHRNN SVPLCNKINR QASPRDWQFS
  3661  TQQIGQLFQK NKLSYLACKL NSLVGNLKTS ESKEVVNKVF NIVSDLFSPD ECLDTGMDSG
  3721  KIQRTYFYSS NNEQPNSILT NNLQLSSKSV FLLNVVCEKL IRILLEECTS TAFPDKGSVS
  3781  EETSAEECQL LKMLQSVEDG KSDYRKGGMD CECLQVDYMS DLLENVAEID QDLLTSDSML
  3841  TIISHSLVKS LMDKLSHSIQ QAPESLPFAN KHLNYRTREI QSSFIKARKS ELIELGQSKS
  3901  SLELRSYDSN SLTVSLNNPS VVSSKIQAPF NKHCAVKSSS VSPFERQRTK EMDKVAIHNK
  3961  LHQEGIYAGV YSATFLEGII SELFFNLSMS LWGKNKNITV SWLNEMNTLF VNNVVNEFNN
  4021  AQVTVLRNAE ERLCFPPVHT ETVSKIVDSV YYDVLQQYEL KVACGNNPVY DNASIAEQIT
  4081  NGILLEILDY KLPSCFKEHL IPHSYYPLKP EIILQKLQSN LTEFTSLPRS SSDYSTMLSH
  4141  SFLEDVIRRL LSQLIPPPIT CSSLGKKYLM SSDFNEMSTC IINKVMSAIS KHKIWFTIYD
  4201  NQYLYTGKNL QKMVDSVYCN ILQMSDSLVS IQKSIVSRSP IMIDQIASFI IQEIIENHLQ
  4261  PFLSGEVLCH PRTPLDPVST IVTQVLSEVI ESHRPQKQSP LDIHLDSFVR EIVARLLSKI
  4321  FSPKHNTEIE LKNMTQRIVN SINRHFNKAK IHILYDDKEQ AFFSFNTDIV DELATSVYRN
  4381  ALKQHGLDLA VDKESEDSGI FVENITNLIV AAISDYLLHP LFSGDFSAST YSNSVAENIV
  4441  QDILSNISKS TEPSQSVPLY NTLLPYTFLE DMIRVLLSKL FSSASSLVLN RDTQKDISRV
  4501  NFNDIASNLV SDIRMKVSQH EIRFSKEEEE TKFIYSEDDI QHLVDSVFAN VVQTSGSQES
  4561  AVQNITSSND ILIDRIAGFI IKHICQKHLQ PFVSGKSLSS SDTYFDDERR QLFYTSVYSS
  4621  TFLEDVISGV LRKIFHRVVG IVQTKSIRDS EDELFEKAEE LIHLITGEFS KAQVSIIDNT
  4681  EERLCLPPVE RDVVKTIVDM VYSKVLQEYE MEVVPNKDFL NDTKTLAARI TNIILAEIFD
  4741  FQIHPDLIAN LPFKSHSKLS ANVLIQRVQY DISKSRFQRQ ASTMYTTMLS HSHLEKIVTQ
  4801  LTSQISPLNT SAEQSDTTKS DLSNTVIKLI NEIMSIISKH EICIIKYGNK KQSMISAKDI
  4861  QSMVDSIYAD LSHSNIYQSI TKDKKSISDI PVSKIASFII KEIFNHHIQS FLSEDKTLLL
  4921  AAVDQTYKLK AIDPKQRELS FIVNSSVFLE EVISELLCKI LYAFSHNMLV TENPDRVKLK
  4981  LTRIVTTLVN SIVLEFTTSE ILVADNFDKN LCFSERYKEM VQKIVNSVYG KVLDQYKSLI
  5041  QIHRVIQSDT ICFGRKIYYL LLEEIYDYQV QSLVSGELES SSYSYPQADN IIRNVLNIIT
  5101  KDSHALPPYI TVLPHSLLED MVYRLLGHVF PSTHTENELK EKKFPPDDEF VEAASKLTDE
  5161  IIKEISEHEI RLSMAEDNAE SMQLEPIENL VDSICNNILK TSEFQAEVQK DADKKGCSFL
  5221  SKLAGFIMKE IMYHHLQPFL HGEESSFSDL SDYDHVSELA KSGKEKTQPS LYSATFLEDI
  5281  IIDLVHKFCS LLIITEDSKK NEMAELDIMG LALKLANSLI REFKKSDIKV LPNAEKMFSF
  5341  PPIDKETVDK ISNFVYEQFI EKCTSHDIQK GDESNIAIGM IAALTQKAIS AFRIQPLFSG
  5401  DWSSTFFSFL NPDNITQRVQ HLPQNTFTQI SRCAKENQLS LPDQSYKDTS STPDCKNMMS
  5461  TLEINRGTMN RKKSFKTKDT SVKKGDIQNP VLSSINAIMK SGMINLTSGL ATGVTNKKEV
  5521  DENKVGICTQ KHSENVSKVT STTTVKSKDT QEPNLSETFN NNEIEKKRNL IPTDKKGKDD
  5581  EIYTHFSLII DDTEYEKEVL GSDSEIGYKK KIDNARESSF KKDDKLFQLS SLKSKRNLGT
  5641  TTDTLEIRIR TSSNEGRRDS PTQTCRDEEH HSDYEHVQNV IENIFEDVLE LSSSPEPAYY
  5701  SKLSYDQSPP GDNVLNVIQE ISRDSAQSVT TKKVSSSTNK NISAKEKEEE EREKEKVREE
  5761  IKSEPSKPDD PQNQRESKPG IFPAKFLEDV ITEMVKQLIF SSIPETQIQD RCQNVSDKQN
  5821  QAKLYDTAMK LINSLLKEFS DAQIKVFRPD KGNQFPGGKV SSVPKVPPRY KEPTTDEAPS
  5881  SIKIKSADKM PPMHKMMRKP SSDKIPSIDK TLVNKVVHSS VCNILNDYGS QDSIWKNINS
  5941  NGENLARRLT SAVINEIFQR QVNLIFCDEV SVSACLPLES KDVVKKVQKL AQTASKECQT
  6001  SSPYTIILPH KFLENVISAL FSKIFSTISS TKTKEPEDNL STELNFLQMK LVSAVATEIS
  6061  QDKYMTIQYV ETLQSDDDEI IQLVVQSVYN NLLPQFGSQE IIQNCVTSGC KILSENIVDL
  6121  VLREVASNQL QSYFCGELTP HQCVEVENIV EKILKDVFQT TDVPLPKPSH ADKLSYNIIE
  6181  EIAVKFLSKL LSIFPKVHKE RTKSLETDMQ KITSKVLNSV QEFISKSKIK LVPPTKESPT
  6241  VPVADNATIE NIVNSIYTSV LKHSGSYTSV FKDLMGKSNV LSDTIGFLMV NAISNSEFQP
  6301  QVEEEVSNSE LVLEAVKIME KVIKIIDELK SKEKSSSRKG LTLDAKLLEE VLALFLAKLI
  6361  RLPSSSSKDE KNLSKTELNK IASQLSKLVT AEISRSSISL IASDPEEHCL NPENTERIYQ
  6421  VVDSVYSNIL QQSGTNKEFY YDIKDTNTAF PKKVASLIID GVSSFPLDTI NSTISNADLS
  6481  GELDVNRIVQ KAQEHAFNVI PELEQEKLDQ NLSEEESPIK IVPHVGKKPV KIDPKIISEH
  6541  LAVISIKTQP LEKLKQECLK RTGHSIAELR RASISGRNYS LGSPDLEKRK TERRTSLDKT
  6601  GRLDVKPLEA VARNSFQNIR KPDITKVELL KDVQSKNDLI VRLVAHDIDQ VYLENYIKEE
  6661  RDSDEDEVVL TQTFAKEEGI KVFEDQVKEV KKPIQSKLSP KSTLSTSSLK KFLSLSKCCQ
  6721  TTASANIEST EAISNQVIES KETHVKRAVA ELDMATPKTM PETASSSWEE KPQCKKEEKN
  6781  LVTEPTHYFI HRIMSSSSYN QEDLISSTGE AEDCHSDPSA KILEESSQEQ KPEHGNSVKF
  6841  ITIFERSKDV LGSANPSKEV ISETPKPDVS KQGSKMLTKM SSTLSKVFSQ CNTNISRSSS
  6901  PAHQDEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 5 nTPM

Expression across tissuesHPA

Tissue

testis: 5 nTPM
stomach: 2.4 nTPM
colon: 1.3 nTPM
rectum: 0.9 nTPM
retina: 0.6 nTPM
pituitary gland: 0.3 nTPM

Single-cell type

late primary spermatocytes: 397 nCPM
early spermatids: 220 nCPM
cardiomyocytes: 187 nCPM
foveolar cells: 173 nCPM
epicardial cells: 166 nCPM
goblet cells: 86 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 3 nTPM
medulla oblongata: 2.6 nTPM
spinal cord: 2.5 nTPM
midbrain: 2.3 nTPM
basal ganglia: 2.2 nTPM
pons: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FSIP2.

Disease | AllUniProt

Conditions FSIP2 is implicated in, by any mechanism.

Spermatogenic failure 34 (SPGF34) MIM:618153

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 1,207 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 34
FSIP2-related disorder
Oligospermia
Reduced sperm motility
Abnormal sperm morphology

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0
gnomAD missense Z: 3.31
DepMap mean gene effect: -0.01
DepMap dependency class: selective

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Fibrous sheath-interacting protein 2, C-terminal
Fibrous sheath-interacting protein 2
Fibrous sheath-interacting protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSIP2 as an antibody target. Whether an autoantibody or antibody against FSIP2 could matter depends on whether native FSIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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