Seroatlas · Human Serome Atlas

FSIP1

Fibrous sheath-interacting protein 1

Also known as: FLJ35989, FSIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA03
Gene: FSIP1
Ensembl: ENSG00000150667
Chromosome: 15
Canonical length: 581 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Flagellar centriole,Annulus

OverviewNCBI Gene

Predicted to act upstream of or within several processes, including axoneme assembly; homeostasis of number of cells within a tissue; and vesicle organization. Predicted to be active in acrosomal vesicle; nucleus; and sperm head. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q8NA03|FSIP1
     1  MDIIKGNLDG ISKPASNSRI RPGSRSSNAS LEVLSTEPGS FKVDTASNLN SGKEDHSESS
    61  NTENRRTSND DKQESCSEKI KLAEEGSDED LDLVQHQIIS ECSDEPKLKE LDSQLQDAIQ
   121  KMKKLDKILA KKQRREKEIK KQGLEMRIKL WEEIKSAKYS EAWQSKEEME NTKKFLSLTA
   181  VSEETVGPSH EEEDTFSSVF HTQIPPEEYE MQMQKLNKDF TCDVERNESL IKSGKKPFSN
   241  TEKIELRGKH NQDFIKRNIE LAKESRNPVV MVDREKKRLV ELLKDLDEKD SGLSSSEGDQ
   301  SGWVVPVKGY ELAVTQHQQL AEIDIKLQEL SAASPTISSF SPRLENRNNQ KPDRDGERNM
   361  EVTPGEKILR NTKEQRDLHN RLREIDEKLK MMKENVLEST SCLSEEQLKC LLDECILKQK
   421  SIIKLSSERK KEDIEDVTPV FPQLSRSIIS KLLNESETKV QKTEVEDADM LESEECEASK
   481  GYYLTKALTG HNMSEALVTE AENMKCLQFS KDVIISDTKD YFMSKTLGIG RLKRPSFLDD
   541  PLYGISVSLS SEDQHLKLSS PENTIADEQE TKDAAEECKE P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

rectum: 10 nTPM
colon: 6.9 nTPM
testis: 6.8 nTPM
choroid plexus: 1.9 nTPM
pituitary gland: 1.3 nTPM
thymus: 1.3 nTPM

Single-cell type

epicardial cells: 666 nCPM
ependymal cells: 235 nCPM
salivary myoepithelial cells: 175 nCPM
platelets: 139 nCPM
monocytes: 135 nCPM
lactotrophs: 135 nCPM

Immune cell

gdT-cell: 0.7 nTPM
MAIT T-cell: 0.5 nTPM
basophil: 0.4 nTPM
eosinophil: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
total PBMC: 0.4 nTPM

Brain region

hypothalamus: 8.2 nTPM
basal ganglia: 8 nTPM
choroid plexus: 7.9 nTPM
cerebral cortex: 7.6 nTPM
amygdala: 7.4 nTPM
midbrain: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Fibrous sheath-interacting protein 1
FSIP1 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSIP1 as an antibody target. Whether an autoantibody or antibody against FSIP1 could matter depends on whether native FSIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...