Seroatlas · Human Serome Atlas

FSHB

Follitropin subunit beta

Also known as: FSHB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01225
Gene
FSHB
Ensembl
ENSG00000131808
Chromosome
11
Canonical length
129 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>P01225|FSHB
     1  MKTLQFFFLF CCWKAICCNS CELTNITIAI EKEECRFCIS INTTWCAGYC YTRDLVYKDP
    61  ARPKIQKTCT FKELVYETVR VPGCAHHADS LYTYPVATQC HCGKCDSDST DCTVRGLGPS
   121  YCSFGEMKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSHB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
199 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 199 nTPM
  • amygdala: 0.7 nTPM
  • cerebellum: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • skin: 0.1 nTPM
  • thymus: 0.1 nTPM

Single-cell type

  • gonadotrophs: 1,606 nCPM
  • pituitary stem cells: 21 nCPM
  • somatotrophs: 8.2 nCPM
  • corticotrophs: 5.5 nCPM
  • thyrotrophs: 3.6 nCPM
  • lactotrophs: 3.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 1.2 nTPM
  • cerebral cortex: 1.1 nTPM
  • amygdala: 0.6 nTPM
  • hippocampal formation: 0.6 nTPM
  • white matter: 0.4 nTPM
  • hypothalamus: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FSHB.

Disease | AllUniProt

Conditions FSHB is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 24 with or without anosmia (HH24) MIM:229070

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypogonadotropic hypogonadism 24 without anosmia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0.34
gnomAD missense Z
0.56
DepMap mean gene effect
0.33
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSHB as an antibody target. Whether an autoantibody or antibody against FSHB could matter depends on whether native FSHB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSHB is annotated as secreted, so native FSHB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FSHB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FSHB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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