Seroatlas · Human Serome Atlas

FSCN3

Fascin-3

Also known as: FSCN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQT6
Gene: FSCN3
Ensembl: ENSG00000106328
Chromosome: 7
Canonical length: 498 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including lamellipodium; microvillus; and ruffle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q9NQT6|FSCN3
     1  MDETEWIHRH PKAEDLRVGL ISWAGTYLTF EACKNTVTAT AKSLGRRQTW EILVSNEHET
    61  QAVVRLKSVQ GLYLLCECDG TVCYGRPRTS HHGCFLLRFH RNSKWTLQCL ISGRYLESNG
   121  KDVFCTSHVL SAYHMWTPRP ALHVHVILYS PIHRCYARAD PTMGRIWVDA AVPCLEECGF
   181  LLHFRDGCYH LETSTHHFLS HVDRLFSQPS SQTAFHMQVR PGGLVALCDG EGGMLYPQGT
   241  HLLLGMGCNP MRGEEWFILQ HCPTWVSLRS KTGRFISVIY DGEVRAASER LNRMSLFQFE
   301  CDSESPTVQL RSANGYYLSQ RRHRAVMADG HPLESDTFFR MHWNCGRIIL QSCRGRFLGI
   361  APNSLLMANV ILPGPNEEFG ILFANRSFLV LRGRYGYVGS SSGHDLIQCN QDQPDRIHLL
   421  PCRPGIYHFQ AQGGSFWSIT SFGTFRPWGK FALNFCIELQ GSNLLTVLAP NGFYMRADQS
   481  GTLLADSEDI TRECIWEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSCN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

testis: 96 nTPM
cerebellum: 0.5 nTPM
bone marrow: 0.4 nTPM
skin: 0.3 nTPM
blood vessel: 0.2 nTPM
endometrium: 0.2 nTPM

Single-cell type

late spermatids: 4,217 nCPM
early spermatids: 399 nCPM
late primary spermatocytes: 32 nCPM
paneth cells: 19 nCPM
epididymal basal cells: 6.3 nCPM
leydig cells: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.4 nTPM
cerebral cortex: 0.7 nTPM
basal ganglia: 0.4 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSCN3 as an antibody target. Whether an autoantibody or antibody against FSCN3 could matter depends on whether native FSCN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSCN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSCN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...