Seroatlas · Human Serome Atlas

FSBP

Fibrinogen silencer-binding protein

Also known as: FSBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95073
Gene: FSBP
Ensembl: ENSG00000265817
Chromosome: 8
Canonical length: 299 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>O95073|FSBP
     1  MVGKARSSNF TLSEKLDLLK LVKPYVKILE EHTNKHSVIV EKNRCWDIIA VNYNAIGVDR
    61  PPRTAQGLRT LYKRLKEYAK QELLQQKETQ SDFKSNISEP TKKVMEMIPQ ISSFCLVRDR
   121  NHIQSANLDE EAQAGTSSLQ VMLDHHPVAI TVEVKQEEDI KPPPPLVLNS QQSDTLEQRE
   181  EHELVHVMER SLSPSLSSVD MRMTSSPSSI PRRDDFFRHE SGEHFRSLLG YDPQILQMLK
   241  EEHQIILENQ KNFGLYVQEK RDGLKRRQQL EEELLRAKIE VEKLKAIRLR HDLPEYNSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

retina: 11 nTPM
epididymis: 2.4 nTPM
ovary: 2.1 nTPM
seminal vesicle: 2 nTPM
prostate: 1.8 nTPM
pituitary gland: 1.7 nTPM

Single-cell type

endometrial ciliated cells: 5.6 nCPM
cone photoreceptor cells: 4.1 nCPM
rod photoreceptor cells: 3.6 nCPM
sertoli cells: 3.4 nCPM
endometrial luminal cells: 2.1 nCPM
breast myoepithelial cells: 1.7 nCPM

Immune cell

naive CD4 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
naive CD8 T-cell: 0.2 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

choroid plexus: 12 nTPM
midbrain: 8.5 nTPM
thalamus: 7.8 nTPM
cerebral cortex: 7.2 nTPM
cerebellum: 7 nTPM
basal ganglia: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 1.57
DepMap mean gene effect: 0.02
DepMap dependency class: selective

OntologyGO

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FSBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

APBA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSBP as an antibody target. Whether an autoantibody or antibody against FSBP could matter depends on whether native FSBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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