Seroatlas · Human Serome Atlas

FSAF1

40S small subunit processome assembly factor 1

Also known as: C1orf131, DKFZp547B1713, FSAF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDD1
Gene: FSAF1
Ensembl: ENSG00000143633
Chromosome: 1
Canonical length: 293 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in chromosome. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q8NDD1|FSAF1
     1  MRVDSSADPT MSQEQGPGSS TPPSSPTLLD ALLQNLYDFG GTEGETEQKK IIKKRENKKR
    61  DVMASAALAA EPSPLPGSLI RGQRKSASSF FKELREERHC APSGTPTGPE ILAAAVPPSS
   121  LKNNREQVEV VEFHSNKKRK LTPDHNKNTK QANPSVLERD VDTQEFNLEK ARLEVHRFGI
   181  TGYGKGKERI LEQERAIMLG AKPPKKSYVN YKVLQEQIKE KKAAKEEEKR LAQETDIFKK
   241  KKRKGQEDRK SKKKSAPSIL SNGRIGQVGK FKNGTLILSP VDIKKINSSR VAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSAF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

duodenum: 20 nTPM
small intestine: 17 nTPM
lymph node: 15 nTPM
tonsil: 14 nTPM
rectum: 14 nTPM
thymus: 13 nTPM

Single-cell type

cytotrophoblasts: 84 nCPM
oocytes: 78 nCPM
migrating cytotrophoblasts: 77 nCPM
extravillous trophoblasts: 72 nCPM
erythrocyte progenitors: 71 nCPM
hepatocytes: 67 nCPM

Immune cell

eosinophil: 37 nTPM
memory B-cell: 34 nTPM
NK-cell: 33 nTPM
T-reg: 31 nTPM
basophil: 30 nTPM
naive B-cell: 30 nTPM

Brain region

cerebellum: 8 nTPM
hypothalamus: 6 nTPM
white matter: 6 nTPM
pons: 5.9 nTPM
medulla oblongata: 5.8 nTPM
spinal cord: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
DepMap mean gene effect: -0.86
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosomal small subunit biogenesis

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

40S small subunit processome assembly factor 1-like
SSU Processome Component
40S small subunit processome assembly factor 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSAF1 as an antibody target. Whether an autoantibody or antibody against FSAF1 could matter depends on whether native FSAF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSAF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSAF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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