Seroatlas · Human Serome Atlas

FRZB

Secreted frizzled-related protein 3

Also known as: FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, hFIZ, SFRP3, SFRP3_HUMAN, SRFP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92765
Gene
FRZB
Ensembl
ENSG00000162998
Chromosome
2
Canonical length
325 aa
Protein class
Disease related genes, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q92765|FRZB
     1  MVCGSPGGML LLRAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM TKMPNHLHHS
    61  TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF QHEPIKPCKS VCERARQGCE
   121  PILIKYRHSW PENLACEELP VYDRGVCISP EAIVTADGAD FPMDSSNGNC RGASSERCKC
   181  KPIRATQKTY FRNNYNYVIR AKVKEIKTKC HDVTAVVEVK EILKSSLVNI PRDTVNLYTS
   241  SGCLCPPLNV NEEYIIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLSK
   301  SDSSNSDSTQ SQKSGRNSNP RQARN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRZB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
317 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 317 nTPM
  • retina: 312 nTPM
  • choroid plexus: 149 nTPM
  • tongue: 109 nTPM
  • spleen: 84 nTPM
  • gallbladder: 37 nTPM

Single-cell type

  • müller glia: 3,403 nCPM
  • retinal pigment epithelial cells: 1,492 nCPM
  • vascular smooth muscle cells: 294 nCPM
  • pericytes: 168 nCPM
  • melanocytes: 163 nCPM
  • goblet cells: 123 nCPM

Immune cell

  • memory B-cell: 0.6 nTPM
  • naive B-cell: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 98 nTPM
  • cerebral cortex: 23 nTPM
  • medulla oblongata: 16 nTPM
  • basal ganglia: 10 nTPM
  • spinal cord: 8.2 nTPM
  • pons: 7.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FRZB.

Disease | AllUniProt

Conditions FRZB is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.95
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRZB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRZB as an antibody target. Whether an autoantibody or antibody against FRZB could matter depends on whether native FRZB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRZB is annotated as secreted, so native FRZB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FRZB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRZB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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