Seroatlas · Human Serome Atlas

FRRS1

Ferric-chelate reductase 1

Also known as: FRRS1_HUMAN, SDFR2, SDR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNA5
Gene: FRRS1
Ensembl: ENSG00000156869
Chromosome: 1
Canonical length: 592 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q6ZNA5|FRRS1
     1  MAVSGFTLGT CILLLHISYV ANYPNGKVTQ SCHGMIPEHG HSPQSVPVHD IYVSQMTFRP
    61  GDQIEVTLSG HPFKGFLLEA RNAEDLNGPP IGSFTLIDSE VSQLLTCEDI QGSAVSHRSA
   121  SKKTEIKVYW NAPSSAPNHT QFLVTVVEKY KIYWVKIPGP IISQPNAFPF TTPKATVVPL
   181  PTLPPVSHLT KPFSASDCGN KKFCIRSPLN CDPEKEASCV FLSFTRDDQS VMVEMSGPSK
   241  GYLSFALSHD QWMGDDDAYL CIHEDQTVYI QPSHLTGRSH PVMDSRDTLE DMAWRLADGV
   301  MQCSFRRNIT LPGVKNRFDL NTSYYIFLAD GAANDGRIYK HSQQPLITYE KYDVTDSPKN
   361  IGGSHSVLLL KVHGALMFVA WMTTVSIGVL VARFFKPVWS KAFLLGEAAW FQVHRMLMFT
   421  TTVLTCIAFV MPFIYRGGWS RHAGYHPYLG CIVMTLAVLQ PLLAVFRPPL HDPRRQMFNW
   481  THWSMGTAAR IIAVAAMFLG MDLPGLNLPD SWKTYAMTGF VAWHVGTEVV LEVHAYRLSR
   541  KVEILDDDRI QILQSFTAVE TEGHAFKKAV LAIYVCGNVT FLIIFLSAIN HL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRRS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

liver: 27 nTPM
placenta: 9.5 nTPM
skin: 8.7 nTPM
epididymis: 6.9 nTPM
esophagus: 6.9 nTPM
vagina: 5 nTPM

Single-cell type

hepatocytes: 110 nCPM
esophageal apical cells: 101 nCPM
syncytiotrophoblasts: 78 nCPM
esophageal suprabasal cells: 59 nCPM
basal keratinocytes: 58 nCPM
suprabasal keratinocytes: 58 nCPM

Immune cell

eosinophil: 12 nTPM
intermediate monocyte: 1.4 nTPM
myeloid DC: 1.3 nTPM
basophil: 1.2 nTPM
classical monocyte: 1 nTPM
plasmacytoid DC: 0.9 nTPM

Brain region

choroid plexus: 11 nTPM
white matter: 10 nTPM
medulla oblongata: 9.2 nTPM
cerebral cortex: 8.9 nTPM
thalamus: 8.9 nTPM
pons: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular iron ion homeostasis

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRRS1 as an antibody target. Whether an autoantibody or antibody against FRRS1 could matter depends on whether native FRRS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRRS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRRS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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