Seroatlas · Human Serome Atlas

FRMPD3

FERM and PDZ domain-containing protein 3

Also known as: FRPD3_HUMAN, KIAA1817, RP5-1070B1.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JV73
Gene
FRMPD3
Ensembl
ENSG00000147234
Chromosome
X
Canonical length
1777 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that contains a PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain at the N-terminus followed by a FERM domain. The encoded protein is involved in signal transduction. The PDZ domain is thought to function in protein-protein interactions, mainly by binding to specific C-terminal peptides of other proteins. The FERM domain is found in proteins that are localized to the plasma membrane and are associated with the cytoskeleton. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

1777 residues, UniProt reviewed canonical sequence.

>Q5JV73|FRMPD3
     1  MQEESANDME CEQLPAEILR QVTVHRDPIY GFGFVAGSER PVVVRSVRPG GPSENKLLAG
    61  DQIVAINEED VSEAPRERLI ELIRSAKEFI VLTVLHTHQS PKSAFISAAK KAKLRSNPVK
   121  VRFSEQVAVG ETDAKMMKKE ALLLIPNVLK VFLENGQIKS FTFDGRTTVK DVMLTLQDRL
   181  SLRFIEHFAL VLEYAGPEQN HKFLLLQDKQ PLAYVVQRTH YHGMKCLFRI SFFPKDPVEL
   241  LRRDPAAFEY LYIQSRNDVI RERFGMDPKP EMLLGLAALH IYITVSATRP SQKISLKNVE
   301  KEWGLEPFLP PSLLQVIKEK NLRKSLSQQL KAHQTHPSCG TKGSAIQAKL QYLRILNELP
   361  TFTGVLFNTV GLDEKQSATT LLVGPRHGIS HVIDLKTNLT TVLSEFSKIS KIQLFRENQG
   421  VARVETSIMD AKPLVLLMEW PEATNFACLI AGYCRLLLDS RKMVFSRPAS QPLPPPMIKA
   481  DYMHSAHRPV TGGHLGKKES SYVGSVGTSP RKSSRCTPPP ADSELVSFCY LHMREQRKEQ
   541  ESRTDVNENL IFFEETRPRT KSDPTSKSSG QGYEVVPDDF DAASLDHEPC ASRARSYTLD
   601  NSLGAEALNF YCDSCKAKLQ EQLGPRKGGK PGSSRDNIVD LMSLPPPGSE EEEEEEDETT
   661  SLLPAIAAPP PGFRDNSSDE DDPKRRAVQS QEQGRHLRGL LYDEIPVTLI DSVQTRTVRD
   721  HAQELDDALV STLQALEALA ASEDGPHPPP PQTAGLIVLA TITPESSLDS GHETNSSELT
   781  DMSEMMSAMK QHQNTTYFLA QHLNKDSLLA RKDLPFRIQS CAAQAVLTAP YSLGRPDPNP
   841  SLQPIATGQS PGPPGARRKL PQSEGQVQGE RTYSLAVHPA LSPQLSEQKN LSLLSPVPED
   901  KGPGHTRAGL EMSLRAATSS LSEEQVSELR DNLPKEVRLS PKLILDPKSS VTPAIISAAL
   961  QQVVHNKSLV TAGGALGNPP SRGERRLEAS MGRPEVSMMS SSASKNLKFK ISPSAPETSW
  1021  NSQHQLGAEV SSSPRAPTGS RADSLHLSQQ EDSLPVQNFP PKSYLLRTSR ESVGKQATGE
  1081  VAGKGGPVGG KPTLQKQGTI SSQGEKAQLE STPKRSKLEE TSLVPRATYP MALQSPSCQS
  1141  RSHSPSCQPH GHSPSSQSRG QSPSCQPRGQ SPLRSQAASR QVSTMPSRKL ETTLNGAHST
  1201  SEGPAKPKSS RGPFRLRNLF SATFPTRQKK ETDERQAQLQ KVKQYELEFL EELLKPPSQG
  1261  ELPGTEYLQP PAPGRCSCQL RSSPVQQGPG MSREQRRSCD CKRICRGGRP QATQTPVPSL
  1321  RGRERDRVLP SQRQPEAGPG VSLSSPINVQ RIRSTSLESR ECRSDPESGV SCLTTCASGG
  1381  ECLGAPNYRK LMRRYSISEL DQGDRASLTS DVYPHPPLGM LPREAKEVEA SLPIALGPKS
  1441  RSLESPTLGD PSYVQVAPET KGPRQMAVFS LPEEVYRKPA ELDEDSESSK CCSIRYCFYY
  1501  RKCDMADDAS DGKDELSYSI PMKILPGMKL DEQVVPVVSR TLQVLDAATC SSSSPEASRT
  1561  QEIDLRVSTF EGSLAKINAL RAHAYGLPDG FLAARLDTNE LLTVLRQCVA SPEARAPKPY
  1621  VSQISEYKLE LALKFKELRA SCRRVANVDK SPTHMLAAIT GSFQVLSSLI ETFVRLVFIV
  1681  RSEAQRQELL AKVEEVVRNY TFLLRAAEES TARNLNQQQQ QQQQQQQQQQ QQQQQQQQQQ
  1741  QQQVAAAAGA ATEHPPGSPT SATVMSTFTH SLKTLIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMPD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 3.6 nTPM
  • cerebral cortex: 3.1 nTPM
  • thyroid gland: 2.6 nTPM
  • ovary: 2.2 nTPM
  • hypothalamus: 1.7 nTPM
  • choroid plexus: 1.3 nTPM

Single-cell type

  • pancreatic islet cells: 61 nCPM
  • choroid plexus epithelial cells: 49 nCPM
  • pituicytes/fscs: 27 nCPM
  • cone photoreceptor cells: 27 nCPM
  • retinal amacrine cells: 22 nCPM
  • astrocytes: 21 nCPM

Immune cell

  • gdT-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • medulla oblongata: 20 nTPM
  • midbrain: 19 nTPM
  • spinal cord: 17 nTPM
  • hypothalamus: 16 nTPM
  • pons: 14 nTPM
  • white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0
gnomAD missense Z
1.02

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRMPD3 as an antibody target. Whether an autoantibody or antibody against FRMPD3 could matter depends on whether native FRMPD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRMPD3 is annotated at the cell surface, where native FRMPD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRMPD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRMPD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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