Seroatlas · Human Serome Atlas

FRMD8P1

Putative FERM domain-containing protein FRMD8P1

Also known as: FR8P1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZ68
Gene: FRMD8P1
Canonical length: 369 aa

OverviewNCBI Gene

No narrative summary is available for FRMD8P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q9BZ68|FRMD8P1
     1  MDGTEGSVGQ PGPTERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLP SLRAHELHCA
    61  VREVLKLPDI ALDVFALWLV SPLLEVQLKP KNQPYKLGRQ WPELLLRFTS APDDDVAMDE
   121  PFLQFRRNVF FPKGRELQIP DEEVLRLLYE EAKGNVLAAR YLCDVEDCEA LGALVCRVQL
   181  VTYQPDWPAA CDLREKLDSF LPAHLCKRGQ GLFAALRGRG ARAGPGEQSL LNAYRKVQEV
   241  SSDGGCEAAL GTHYRAYLLK CHKLPFYGCA FFHGEVDKPA QGFLHRGGRK SVSVAISLEG
   301  VHVVDSREKH VLLGLCFQEL SWDHTSPEEE EPILWLEFDR DSGVTPVNKL LKIYSKQAEL
   361  MSSLIEYCI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMD8P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33

OntologyGO

Biological processes

negative regulation of canonical Wnt signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRMD8P1 as an antibody target. Whether an autoantibody or antibody against FRMD8P1 could matter depends on whether native FRMD8P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRMD8P1 is annotated at the cell surface, where native FRMD8P1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRMD8P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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