Seroatlas · Human Serome Atlas

FRMD8

FERM domain-containing protein 8

Also known as: FKSG44, FLJ90369, FRMD8_HUMAN, iTAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZ67
Gene: FRMD8
Ensembl: ENSG00000126391
Chromosome: 11
Canonical length: 464 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Centriolar satellite,Cytosol

OverviewNCBI Gene

Involved in positive regulation of tumor necrosis factor production. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q9BZ67|FRMD8
     1  MDGTEGSAGQ PGPAERSHRS SVSSVGARAA DVLVYLADDT VVPLAVENLP SLSAHELHRA
    61  VREVLQLPDI ALDVFALWLV SPLLEVQLKP KHQPYKLGRQ WPELLLRFTS APDDDVAMDE
   121  PFLQFRRNVF FPKRRELQIH DEEVLRLLYE EAKGNVLAAR YPCDVEDCEA LGALVCRVQL
   181  GPYQPGRPAA CDLREKLDSF LPAHLCKRGQ SLFAALRGRG ARAGPGEQGL LNAYRQVQEV
   241  SSDGGCEAAL GTHYRAYLLK CHELPFYGCA FFHGEVDKPA QGFLHRGGRK PVSVAISLEG
   301  VHVIDSREKH VLLGLRFQEL SWDHTSPEEE EPILWLEFDG DSEGTPVNKL LKIYSKQAEL
   361  MSSLIEYCIE LSQAAEPAGP QDSATGSPSD PSSSLAPVQR PKLRRQGSVV SSRIQHLSTI
   421  DYVEDGKGIR RVKPKRTTSF FSRQLSLGQG SYTVVQPGDS LEQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

spleen: 39 nTPM
esophagus: 36 nTPM
skin: 33 nTPM
vagina: 25 nTPM
small intestine: 23 nTPM
lung: 23 nTPM

Single-cell type

esophageal apical cells: 152 nCPM
urothelial cells: 126 nCPM
suprabasal keratinocytes: 90 nCPM
esophageal suprabasal cells: 88 nCPM
ocular epithelial cells: 80 nCPM
esophageal basal cells: 64 nCPM

Immune cell

neutrophil: 23 nTPM
non-classical monocyte: 20 nTPM
eosinophil: 18 nTPM
memory CD8 T-cell: 17 nTPM
MAIT T-cell: 14 nTPM
plasmacytoid DC: 13 nTPM

Brain region

white matter: 33 nTPM
cerebral cortex: 30 nTPM
hippocampal formation: 27 nTPM
medulla oblongata: 27 nTPM
cerebellum: 25 nTPM
thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.11
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRMD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRMD8 as an antibody target. Whether an autoantibody or antibody against FRMD8 could matter depends on whether native FRMD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRMD8 is annotated at the cell surface, where native FRMD8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FRMD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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