Seroatlas · Human Serome Atlas

FRMD1

FERM domain-containing protein 1

Also known as: bA164L23.1, DKFZp434O0117, FLJ00181, FLJ22615, FLJ40260, FRMD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N878
Gene: FRMD1
Ensembl: ENSG00000153303
Chromosome: 6
Canonical length: 549 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of hippo signaling. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasmic side of apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q8N878|FRMD1
     1  MAVPPRGRGI DPARTNPDTF PPSGARCMEP SPERPACSQQ EPTLGMDAMA SEHRDVLVLL
    61  PSREQLRLAV GVKATGRELF QQVCNVASIR DAQFFGLCVV RNNEYIFMDL EQKLSKYFSK
   121  DWKKERNEGN EKPRAPFVAF LRVQHYVENG RVISDHRARH LYYCHLKERV LRSQCAHREE
   181  AYFLLAACAL QADLGEHRES AHAGRYFEPH SYFPQWIITK RGIDYILRHM PTLHRERQGL
   241  SPKEAMLCFI QEACRLEDVP VHFFRLHKDK KEGRPTVILG LALRGVHIYQ GKKLEIQLDG
   301  LPAAQKLVYY TGCTWRSRHL LHLLRASHQL HLRVRPTLQQ LRQREEAEEK QHYRESYISD
   361  ELELDLASRS FPGSGVSSQH CPHCLSRHSA DSHGSSYTSG IKANSWLRES REMSVDVPLE
   421  VHGLHEKEPS SSPRTSRSHP STRGDSQATR QEPCTQVRTR GQSAEAVHQI QEMTAGVSEE
   481  QHSHGLDDMQ LHQLALHPAP TSLSHTFHRA LDCRLAGPCE TRATLPSKRS SNCLALDLFG
   541  EAPPQEFVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

stomach: 14 nTPM
thymus: 9.6 nTPM
kidney: 5.5 nTPM
testis: 5.4 nTPM
colon: 5.3 nTPM
adipose tissue: 3.3 nTPM

Single-cell type

podocytes: 166 nCPM
parietal cells: 149 nCPM
colonocytes: 88 nCPM
proximal tubule cells: 31 nCPM
enterocytes: 30 nCPM
goblet cells: 25 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of hippo signaling

Cellular components

cytoplasmic side of apical plasma membrane

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRMD1 as an antibody target. Whether an autoantibody or antibody against FRMD1 could matter depends on whether native FRMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRMD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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