Seroatlas · Human Serome Atlas

FRG2C

Protein FRG2-like-2

Also known as: FRG2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NGY1
Gene
FRG2C
Ensembl
ENSG00000172969
Chromosome
3
Canonical length
282 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>A6NGY1|FRG2C
     1  MGKGNEDPDL HCSSIQCSTD QPPFQQISFT EKGSDEKKPF KGKGKTAFSH SSEKHTQRQA
    61  GSDPNPNKEN SEETKLKAGN STAGSEPESS SYQENCRKRK ISSKDICQDR AGNCPEEECN
   121  LTLNKKSRSS TAVHNSEIQE TCDAHHRGSS RACTGRSKRH RSRALEVQTP SLRKSLVTSV
   181  RAMSEAVYQD LAQVWAQQIH SPLTCEQLTL LTRLRGPLCA QVQTLYSMAT QAAYVFPAES
   241  WLVPATLPGP GDSALDREAH PFPGQEITEP VSGSDEAKLG AP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRG2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
1.4 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 1.4 nTPM
  • testis: 0.7 nTPM
  • cerebral cortex: 0.1 nTPM
  • skin: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • late spermatids: 40 nCPM
  • early spermatids: 18 nCPM
  • late primary spermatocytes: 1.2 nCPM
  • loop of henle epithelial cells: 1 nCPM
  • adipocytes: 0.9 nCPM
  • undifferentiated spermatogonia: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 2.1 nTPM
  • hippocampal formation: 2.1 nTPM
  • amygdala: 2 nTPM
  • cerebral cortex: 1.8 nTPM
  • pons: 1.8 nTPM
  • thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect
-0.3
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRG2C as an antibody target. Whether an autoantibody or antibody against FRG2C could matter depends on whether native FRG2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRG2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRG2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRG2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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