Seroatlas · Human Serome Atlas

FRG2B

Protein FRG2-like-1

Also known as: FRG2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QU4
Gene: FRG2B
Ensembl: ENSG00000225899
Chromosome: 10
Canonical length: 278 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q96QU4|FRG2B
     1  MGKGNEDPDL HCSSIQCSTD QPPFQQISFT EKGSDEKKPF KEKGKTAFSH SSEKHIQRQG
    61  SEPNPNKENS EETKLKAGNS TAGSEPESSS YRENCRKRKM SSKDSCQDTA GNCPEKECSL
   121  SLNKKSRSST PVHNSEIQET CDAHHRGRSR ACTGRSKRHR SRALGVQTPS IRKSLVTSVR
   181  AMSEAVYQDL AQVWAQQIHS PLTCEQLTLL TRLRGPLCAQ VQTLYSMATQ AAYVFPAESW
   241  LVPATLPGPG ESALDREAHP FPGQEITETV SGSDEAKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRG2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

kidney: 0.3 nTPM
cerebellum: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

lactotrophs: 0.1 nCPM
rod photoreceptor cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2 nTPM
cerebellum: 1.6 nTPM
white matter: 1.4 nTPM
pons: 1.3 nTPM
choroid plexus: 1.1 nTPM
medulla oblongata: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0.18
gnomAD missense Z: -0.32
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRG2B as an antibody target. Whether an autoantibody or antibody against FRG2B could matter depends on whether native FRG2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRG2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRG2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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