Seroatlas · Human Serome Atlas

FRG2

Protein FRG2

Also known as: FRG2_HUMAN, FRG2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q64ET8
Gene
FRG2
Ensembl
ENSG00000205097
Chromosome
4
Canonical length
278 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q64ET8|FRG2
     1  MGKGNEDSDL HCSSIQCSTD QPPFQQISFT EKGSDEKKPF KEKGKTAFSH SSEKHIQRQG
    61  SEPNPNKENS EETKLKAGNS TAGSEPESSS YRENCRKRKM SSKDSCQDTA GNCPEKECSL
   121  SLNKKSRSST AVHNSEIQET CDAHHRGHSR ACTGHSKRHR SRALGVQTPS IRKSLVTSVR
   181  AMSEAVYQDL AQVWAQQIHS PLTCEQLTLL TRLRGPLCAQ VQTLYSMATQ AAYVFPAESW
   241  LVPATLPGPG ESALDREAHP FPGQEITETV SGSDEAKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
0.3 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 0.3 nTPM
  • skin: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.4 nTPM
  • white matter: 0.4 nTPM
  • pons: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0.37
gnomAD missense Z
0.02

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRG2 as an antibody target. Whether an autoantibody or antibody against FRG2 could matter depends on whether native FRG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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