Seroatlas · Human Serome Atlas

FREY1

Protein Frey 1

Also known as: C11orf94, Frey, FREY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JXX5
Gene: FREY1
Ensembl: ENSG00000234776
Chromosome: 11
Canonical length: 98 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization; maintenance of protein localization in endoplasmic reticulum; and sperm-egg recognition. Predicted to act upstream of or within several processes, including protein modification process; protein stabilization; and spermatid development. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>C9JXX5|FREY1
     1  MVLAMLGALH PRAGLSLFLH LILAVALLRS QPLRSQRSVP EAFSAPLELS QPLSGLVDDY
    61  GILPKHPRPR GPRPLLSRAQ QRKRDGPDLA EYYYDAHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FREY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
esophagus: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 436 nCPM
late spermatids: 264 nCPM
late primary spermatocytes: 198 nCPM
cone photoreceptor cells: 2.1 nCPM
sertoli cells: 2 nCPM
peritubular myoid cells: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.3 nTPM
cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0.04
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

Protein Frey
Protein Frey

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FREY1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FREY1 as an antibody target. Whether an autoantibody or antibody against FREY1 could matter depends on whether native FREY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FREY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FREY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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