Seroatlas · Human Serome Atlas

FRAT2

GSK-3-binding protein FRAT2

Also known as: FRAT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75474
Gene: FRAT2
Ensembl: ENSG00000181274
Chromosome: 10
Canonical length: 233 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>O75474|FRAT2
     1  MPCRREEEEE AGEEAEGEEE EDDSFLLLQQ SVTLGSSGEV DRLVAQIGET LQLDAAQDSP
    61  ASPCAPPGVP LRAPGPLAAA VPADKARPPA VPLLLPPASA ETVGPAPSGA LRCALGDRGR
   121  VRGRAAPYCV AEVAAGPSAL PGPCRRGWLR DAVTSRRLQQ RRWTQAGARA GDDDPHRLLQ
   181  QLVLSGNLIK EAVRRLQRAV AAVAATGPAS APGPGGGRSG PDRIALQPSG SLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
spleen: 27 nTPM
duodenum: 24 nTPM
skin: 20 nTPM
liver: 18 nTPM
colon: 16 nTPM

Single-cell type

neutrophils: 286 nCPM
neutrophil progenitors: 77 nCPM
late spermatids: 65 nCPM
endometrial luminal cells: 64 nCPM
breast lactating cells: 49 nCPM
early spermatids: 46 nCPM

Immune cell

neutrophil: 58 nTPM
eosinophil: 15 nTPM
basophil: 8.3 nTPM
non-classical monocyte: 7.9 nTPM
classical monocyte: 7.2 nTPM
intermediate monocyte: 4.8 nTPM

Brain region

choroid plexus: 15 nTPM
medulla oblongata: 11 nTPM
cerebellum: 11 nTPM
midbrain: 11 nTPM
thalamus: 10 nTPM
cerebral cortex: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0.05
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Wnt signaling pathway

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRAT2 as an antibody target. Whether an autoantibody or antibody against FRAT2 could matter depends on whether native FRAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRAT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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