Seroatlas · Human Serome Atlas

FPR1

fMet-Leu-Phe receptor

Also known as: FMLP, FPR, FPR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P21462
Gene: FPR1
Ensembl: ENSG00000171051
Chromosome: 19
Canonical length: 350 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P21462|FPR1
     1  METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV AGFRMTHTVT
    61  TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF VFTIVDINLF GSVFLIALIA
   121  LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW VMALLLTLPV IIRVTTVPGK TGTVACTFNF
   181  SPWTNDPKER INVAVAMLTV RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL
   241  RVLSFVAAAF FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML
   301  YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FPR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 179 nTPM
spleen: 175 nTPM
appendix: 154 nTPM
lung: 66 nTPM
adipose tissue: 64 nTPM
urinary bladder: 62 nTPM

Single-cell type

neutrophils: 3,551 nCPM
monocytes: 454 nCPM
neutrophil progenitors: 341 nCPM
hofbauer cells: 222 nCPM
cdc: 203 nCPM
macrophages: 177 nCPM

Immune cell

neutrophil: 4,198 nTPM
classical monocyte: 759 nTPM
total PBMC: 420 nTPM
intermediate monocyte: 319 nTPM
basophil: 318 nTPM
eosinophil: 204 nTPM

Brain region

white matter: 32 nTPM
medulla oblongata: 27 nTPM
thalamus: 17 nTPM
spinal cord: 16 nTPM
cerebral cortex: 16 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.55
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FPR1 as an antibody target. Whether an autoantibody or antibody against FPR1 could matter depends on whether native FPR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FPR1 is annotated at the cell surface, where native FPR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FPR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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