FPGT

Protein identityUniProt · HPA

UniProt accession

O14772

Gene

FPGT

Ensembl

ENSG00000254685

Chromosome

1

Canonical length

607 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>O14772|FPGT
     1  MRAVRRGLRE GGAMAAARDP PEVSLREATQ RKLRRFSELR GKLVARGEFW DIVAITAADE
    61  KQELAYNQQL SEKLKRKELP LGVQYHVFVD PAGAKIGNGG STLCALQCLE KLYGDKWNSF
   121  TILLIHSGGY SQRLPNASAL GKIFTALPLG NPIYQMLELK LAMYIDFPLN MNPGILVTCA
   181  DDIELYSIGE FEFIRFDKPG FTALAHPSSL TIGTTHGVFV LDPFDDLKHR DLEYRSCHRF
   241  LHKPSIEKMY QFNAVCRPGN FCQQDFAGGD IADLKLDSDY VYTDSLFYMD HKSAKMLLAF
   301  YEKIGTLSCE IDAYGDFLQA LGPGATVEYT RNTSNVIKEE SELVEMRQRI FHLLKGTSLN
   361  VVVLNNSKFY HIGTTEEYLF YFTSDNSLKS ELGLQSITFS IFPDIPECSG KTSCIIQSIL
   421  DSRCSVAPGS VVEYSRLGPD VSVGENCIIS GSYILTKAAL PAHSFVCSLS LKMNRCLKYA
   481  TMAFGVQDNL KKSVKTLSDI KLLQFFGVCF LSCLDVWNLK VTEELFSGNK TCLSLWTARI
   541  FPVCSSLSDS VITSLKMLNA VKNKSAFSLN SYKLLSIEEM LIYKDVEDMI TYREQIFLEI
   601  SLKSSLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FPGT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

18 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.28

gnomAD pLI

0

gnomAD missense Z

-0.9

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fucose metabolic process
• GDP-L-fucose biosynthetic process

Molecular functions

• GTP binding
• fucose-1-phosphate guanylyltransferase activity

Cellular components

• cytoplasm
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Trimeric LpxA-like superfamily
• GDP-fucose pyrophosphorylase domain
• Fucose pyrophosphorylase domain
• Fucose-1-phosphate guanylyltransferase

KeywordsUniProt

• Cytoplasm
• GTP-binding
• Nucleotide-binding
• Nucleotidyltransferase
• Transferase