Seroatlas · Human Serome Atlas

FOXL2NB

FOXL2 neighbor protein

Also known as: C3orf72, FLJ43329, FOXNB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZUU3
Gene
FOXL2NB
Ensembl
ENSG00000206262
Chromosome
3
Canonical length
175 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center

OverviewNCBI Gene

Located in fibrillar center. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q6ZUU3|FOXL2NB
     1  MTRTPVGSAR TRPKPRKLGP QRGKALQASS RLSESPALVK KRMPDACTLG RAGIGLPKMC
    61  LHMAVRHSKA QKTGPGILQQ RQKPPAPRAS GGPALLGKRR GCSEAGSASL EPLSSSRAAA
   121  GCLNQVPLSP FLAGPRNTRR LPAPERERIE LAATLCLEGW PLRCLASKGK LHCVY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOXL2NB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 54 nTPM
  • parathyroid gland: 31 nTPM
  • cervix: 21 nTPM
  • fallopian tube: 18 nTPM
  • endometrium: 17 nTPM
  • pituitary gland: 9.6 nTPM

Single-cell type

  • gonadotrophs: 46 nCPM
  • granulosa cells: 24 nCPM
  • ovarian stromal cells: 18 nCPM
  • thyrotrophs: 12 nCPM
  • decidual stromal cells: 9.2 nCPM
  • oocytes: 9.2 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • naive B-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 8.9 nTPM
  • cerebral cortex: 8.3 nTPM
  • hypothalamus: 7.9 nTPM
  • pons: 7.8 nTPM
  • amygdala: 7.7 nTPM
  • white matter: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOXL2NB as an antibody target. Whether an autoantibody or antibody against FOXL2NB could matter depends on whether native FOXL2NB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOXL2NB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FOXL2NB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOXL2NB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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