Seroatlas · Human Serome Atlas

FOLR3

Folate receptor gamma

Also known as: FOLR3_HUMAN, FR-G, FRgamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41439
Gene: FOLR3
Ensembl: ENSG00000110203
Chromosome: 11
Canonical length: 245 aa
Protein class: Metabolic proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>P41439|FOLR3
     1  MDMAWQMMQL LLLALVTAAG SAQPRSARAR TDLLNVCMNA KHHKTQPSPE DELYGQCSPW
    61  KKNACCTAST SQELHKDTSR LYNFNWDHCG KMEPTCKRHF IQDSCLYECS PNLGPWIRQV
   121  NQSWRKERIL NVPLCKEDCE RWWEDCRTSY TCKSNWHKGW NWTSGINECP AGALCSTFES
   181  YFPTPAALCE GLWSHSFKVS NYSRGSGRCI QMWFDSAQGN PNEEVAKFYA AAMNAGAPSR
   241  GIIDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOLR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 90 nTPM
spleen: 31 nTPM
appendix: 9.6 nTPM
kidney: 6.1 nTPM
lung: 5.4 nTPM
adipose tissue: 5.2 nTPM

Single-cell type

neutrophils: 186 nCPM
neutrophil progenitors: 75 nCPM
monocyte progenitors: 46 nCPM
monocytes: 44 nCPM
late spermatids: 21 nCPM
respiratory ionocytes: 15 nCPM

Immune cell

neutrophil: 490 nTPM
classical monocyte: 325 nTPM
total PBMC: 293 nTPM
myeloid DC: 36 nTPM
eosinophil: 30 nTPM
intermediate monocyte: 25 nTPM

Brain region

thalamus: 0.8 nTPM
cerebral cortex: 0.6 nTPM
hypothalamus: 0.3 nTPM
midbrain: 0.3 nTPM
pons: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0.02
gnomAD missense Z: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOLR3 as an antibody target. Whether an autoantibody or antibody against FOLR3 could matter depends on whether native FOLR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOLR3 is annotated as secreted, so native FOLR3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FOLR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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