Seroatlas · Human Serome Atlas

FOLR2

Folate receptor beta

Also known as: FOLR2_HUMAN, FRbeta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14207
Gene
FOLR2
Ensembl
ENSG00000165457
Chromosome
11
Canonical length
255 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>P14207|FOLR2
     1  MVWKWMPLLL LLVCVATMCS AQDRTDLLNV CMDAKHHKTK PGPEDKLHDQ CSPWKKNACC
    61  TASTSQELHK DTSRLYNFNW DHCGKMEPAC KRHFIQDTCL YECSPNLGPW IQQVNQSWRK
   121  ERFLDVPLCK EDCQRWWEDC HTSHTCKSNW HRGWDWTSGV NKCPAGALCR TFESYFPTPA
   181  ALCEGLWSHS YKVSNYSRGS GRCIQMWFDS AQGNPNEEVA RFYAAAMHVN AGEMLHGTGG
   241  LLLSLALMLQ LWLLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOLR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
158 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 158 nTPM
  • adipose tissue: 111 nTPM
  • urinary bladder: 76 nTPM
  • gallbladder: 75 nTPM
  • lymph node: 74 nTPM
  • adrenal gland: 52 nTPM

Single-cell type

  • hofbauer cells: 2,521 nCPM
  • kupffer cells: 508 nCPM
  • macrophages: 209 nCPM
  • cdc: 48 nCPM
  • monocytes: 31 nCPM
  • microglia: 28 nCPM

Immune cell

  • classical monocyte: 64 nTPM
  • intermediate monocyte: 51 nTPM
  • total PBMC: 20 nTPM
  • myeloid DC: 19 nTPM
  • non-classical monocyte: 14 nTPM
  • memory B-cell: 9.6 nTPM

Brain region

  • thalamus: 19 nTPM
  • white matter: 18 nTPM
  • choroid plexus: 15 nTPM
  • cerebral cortex: 11 nTPM
  • pons: 9.5 nTPM
  • basal ganglia: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.42
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOLR2 as an antibody target. Whether an autoantibody or antibody against FOLR2 could matter depends on whether native FOLR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOLR2 is annotated at the cell surface, where native FOLR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FOLR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOLR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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