Seroatlas · Human Serome Atlas

FOLR1

Folate receptor alpha

Also known as: FOLR, FOLR1_HUMAN, FRalpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15328
Gene
FOLR1
Ensembl
ENSG00000110195
Chromosome
11
Canonical length
257 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>P15328|FOLR1
     1  MAQRMTTQLL LLLVWVAVVG EAQTRIAWAR TELLNVCMNA KHHKEKPGPE DKLHEQCRPW
    61  RKNACCSTNT SQEAHKDVSY LYRFNWNHCG EMAPACKRHF IQDTCLYECS PNLGPWIQQV
   121  DQSWRKERVL NVPLCKEDCE QWWEDCRTSY TCKSNWHKGW NWTSGFNKCA VGAACQPFHF
   181  YFPTPTVLCN EIWTHSYKVS NYSRGSGRCI QMWFDPAQGN PNEEVARFYA AAMSGAGPWA
   241  AWPFLLSLAL MLLWLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOLR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
2,861 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 2,861 nTPM
  • salivary gland: 207 nTPM
  • lung: 182 nTPM
  • fallopian tube: 176 nTPM
  • kidney: 143 nTPM
  • cervix: 116 nTPM

Single-cell type

  • breast lactating cells: 1,704 nCPM
  • fallopian tube ciliated cells: 789 nCPM
  • migrating cytotrophoblasts: 547 nCPM
  • cytotrophoblasts: 460 nCPM
  • transitional alveolar cells: 450 nCPM
  • alveolar cells type 1: 426 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 994 nTPM
  • hippocampal formation: 26 nTPM
  • cerebellum: 23 nTPM
  • midbrain: 14 nTPM
  • thalamus: 14 nTPM
  • medulla oblongata: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOLR1.

Disease | AllUniProt

Conditions FOLR1 is implicated in, by any mechanism.

  • Neurodegeneration due to cerebral folate transport deficiency (NCFTD) MIM:613068

Disease | GeneticClinVar

31 pathogenic / likely-pathogenic of 291 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on FOLR1 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against FOLR1 are reported. Each links to that disease's full target list.

    Showing 0 of 3 — disease pages carrying at least 10 antigens.

    ReferencesPubMed · IEDB

    Publications for FOLR1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

    Reference: AutoantibodyPubMed

    34 publications

    Show 20 more of 34 total

    Reference: B cellIEDB

    1 publication

    Reference: T cellIEDB

    2 publications

    Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

    Genetic constraint and essentialitygnomAD · DepMap

    Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

    gnomAD LOEUF (loss-of-function intolerance)
    0.65
    gnomAD pLI
    0.13
    gnomAD missense Z
    0.67
    DepMap mean gene effect
    -0.03
    DepMap dependency class
    selective

    Cancer expressionTCGA

    Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

    OntologyGO

    Biological processes

    Molecular functions

    Cellular components

    Protein domainsUniProt · Pfam · InterPro

    KeywordsUniProt

    Antibody and autoantibody relevanceSeroatlas analysis

    Seroatlas reads FOLR1 as an antibody target. Whether an autoantibody or antibody against FOLR1 could matter depends on whether native FOLR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

    FOLR1 is annotated at the cell surface, where native FOLR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

    Annotation status

    The present source text does not explicitly label FOLR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

    Canonical record: https://seroatlas.com/gene/FOLR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

    Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

    © 2026 · Seroatlas, Discover Oregon LLC · Terms of use

    Loading the interactive Seroatlas protein explorer...