Seroatlas · Human Serome Atlas

FOCAD

Focadhesin

Also known as: FLJ20375, FOCAD_HUMAN, KIAA1797

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VW36
Gene
FOCAD
Ensembl
ENSG00000188352
Chromosome
9
Canonical length
1801 aa
Protein class
Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to be involved in regulation of post-transcriptional gene silencing. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1801 residues, UniProt reviewed canonical sequence.

>Q5VW36|FOCAD
     1  MSDDIRKRFE FPNSLIQSQA VGHLIAAVLK ENGFSEKIHQ STNQTPALNL LWEKCCSDNV
    61  VVRTACCEGL VALVAQDHAE FSYVLNGILN LIPSTRNTHG LIKAIMHLLQ MQALKEGQGG
   121  EKNIQSIYTI RNHPHPLITV LEHRPDCWPV FLQQLTAFFQ QCPERLEVSC IQIMAPFLWY
   181  LYCEPSQLQE YAKLRLALLK VLLQPQVLCD KDQPSILEQQ ILQLCCDIVP CLQVKDLIQT
   241  TEAMMFIEEV CLSLLRHPVF WKIQLTQMSL QLLCVSEVSL KITGECSSSI HLLEHSVELL
   301  KEDFPVELVI IGIALLLLQT PASQQKPILN LALKLLSVTE DQKIPKSSLL LVMPILQILS
   361  STALEDCISV DEEGPSRQQL ALNLLEMIQQ ECYRDDHQKL SYKLVCPVTS MYGTIFTAWR
   421  ILEVMTDSSA ASDWLASVES LLPITAVIPA PAFLLLAHLL VEDKGQNLHQ ILKVTTELAQ
   481  ADSSQVPNLI PVLMFKLGRP LEPILYNDIL YTLPKLGVHK VCIGQILRII QLLGTTPRLR
   541  AVTLRLLTSL WEKQDRVYPE LQRFMAVSDV PSLSVGKEVQ WEKLIAKAAS IRDICKQRPY
   601  QHGADMLAAI SQVLNECTKP DQATPAALVL QGLHALCQAE VVCIRSTWNA LSPKLSCDTR
   661  PLILKTLSEL FSLVPSLTVN TTEYENFKVQ VLSFLWTHTQ NKDPIVANAA YRSLANFSAG
   721  EHTILHLPEK IRPEIPIPEE LDDDEDVEDV DLSVPGSCYL KLLSLTPPLV LPALEEFFTS
   781  LVKQEMVNMP RGIYHSALKG GARSDQGKTV AGIPNFILKM YETNKQPGLK PGLAGGMLFC
   841  YDVSMYQSKD GKPLNRLMAS RGRSFKQTSL ALVHEVHIQL SEWHRAIFLP QAWLAYMNRA
   901  YHAILQGRLG ELELQLKHGK EEPEEVQYKK STAWLWVRDM LTDEITKAAA KESPVVKGNA
   961  LLALSSLAVV VSRHEASLSS DSDGLLEVQP NFLSMKEWVS MVLDTLLVIV DSHYQPRGQL
  1021  LSWFYYKSYS GENTASAIAR SAAATALSLL VPVFIISCKE KVEEILNMLT ARLPGKPSAD
  1081  ESQAVQIHMG LALGMFLSRL CEEKLSDISG QEMNLLLMKS LDALENCCFD TSLEYNTGCI
  1141  LGVGLVLSLM SHSSQMQSRV HVAALLRKLS AHVDDSGSQS RTFQEVLAYT LSCVCTSAFS
  1201  AGIIEATEAE DVMNKLRLLV ENSQQTSGFA LALGNIVHGL SVCGHGKAED LGSKLLPAWI
  1261  RIVLTEGTPT MLCLAALHGM VALVGSEGDV MQLKSEAIQT SHFQGRLNEV IRTLTQVISV
  1321  SGVIGLQSNA VWLLGHLHLS TLSSSQSRAS VPTDYSYLPE SSFIGAAIGF FITGGKKGPE
  1381  SVPPSLLKVV MKPIATVGES YQYPPVNWAA LLSPLMRLNF GEEIQQLCLE IMVTQAQSSQ
  1441  NAAALLGLWV TPPLIHSLSL NTKRYLLISA PLWIKHISDE QILGFVENLM VAVFKAASPL
  1501  GSPELCPSAL HGLSQAMKLP SPAHHLWSLL SEATGKIFDL LPNKIRRKDL ELYISIAKCL
  1561  LEMTDDDANR IAQVTKSNIE KAAFVKLYLV SQGRFPLVNL TDMLSVAVQH REKEVLAWMI
  1621  LHSLYQARIV SHANTGVLKR MEWLLELMGY IRNVAYQSTS FHNTALDKAL DFFLLIFATA
  1681  VVAWADHTAP LLLGLSASWL PWHQENGPAG PVPSFLGRSP MHRVTLQEVL TLLPNSMALL
  1741  LQKEPWKEQT QKFIDWLFSI MESPKEALSA QSRDLLKATL LSLRVLPEFK KKAVWTRAYG
  1801  W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FOCAD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 35 nTPM
  • thyroid gland: 18 nTPM
  • thymus: 10 nTPM
  • adrenal gland: 9.7 nTPM
  • fallopian tube: 9.3 nTPM
  • parathyroid gland: 9 nTPM

Single-cell type

  • choroid plexus epithelial cells: 1,040 nCPM
  • somatotrophs: 502 nCPM
  • gonadotrophs: 499 nCPM
  • brain inhibitory neurons: 497 nCPM
  • brain excitatory neurons: 495 nCPM
  • lactotrophs: 468 nCPM

Immune cell

  • basophil: 6.6 nTPM
  • MAIT T-cell: 3.5 nTPM
  • myeloid DC: 2.9 nTPM
  • intermediate monocyte: 2.6 nTPM
  • naive CD8 T-cell: 2.5 nTPM
  • NK-cell: 2.5 nTPM

Brain region

  • choroid plexus: 260 nTPM
  • hippocampal formation: 69 nTPM
  • hypothalamus: 68 nTPM
  • cerebral cortex: 67 nTPM
  • white matter: 60 nTPM
  • basal ganglia: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FOCAD.

Disease | AllUniProt

Conditions FOCAD is implicated in, by any mechanism.

  • Liver disease, severe congenital (SCOLIV) MIM:619991

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 1,107 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Liver disease, severe congenital
  • FOCAD-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
-2.93
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

  • regulation of post-transcriptional gene silencing

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Armadillo-type fold
  • Focadhesin, C-terminal domain
  • Focadhesin/RST, DUF3730
  • Focadhesin/RST1
  • Focadhesin
  • Focadhesin/RST1, DUF3730

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FOCAD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FOCAD as an antibody target. Whether an autoantibody or antibody against FOCAD could matter depends on whether native FOCAD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FOCAD is annotated at the cell surface, where native FOCAD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FOCAD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FOCAD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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