Seroatlas · Human Serome Atlas

FNDC7

Fibronectin type III domain-containing protein 7

Also known as: FLJ35838, FNDC7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VTL7
Gene: FNDC7
Ensembl: ENSG00000143107
Chromosome: 1
Canonical length: 733 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Actin filaments
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

733 residues, UniProt reviewed canonical sequence.

>Q5VTL7|FNDC7
     1  MAGGRETCLP LIGFILICLK MVASAKSAPE IPTIDQAYSK LSNSITVEWA TVPGATSYLL
    61  TAEDGDTVIE TTVANSPGTV TGLKAATWYE ITIRSISAAG RSQASPPKQA KTVLAAPILE
   121  VSSPSSDSIL VQWEAVYMAI AFSVSIMRAN GLGSIWKENT TNTSLTFTSL EAGTLYTIKA
   181  YAWNANRIPG DDSTCNQRTS PRAPANIQVS FDSGALKASF SWARAEGAFN YTVMALSDSS
   241  ELTCSTTFSS CTISSLQCGT EYLISVLASN DAGSSKSSSA MTLKTVACAP GRVTIQEDPP
   301  GHLSVAWSSV DLGDYYVVFV KSDDGLEVHC NTSLTQCNFL SECGFTYFIS VFVYNKAGQS
   361  PLGDIFNYTT APCCPSDINP VLVSSDRVEI VWSPVRGAEL YETKAVDGYN MVECNDTTPA
   421  CTLSALECDT KYNITVYSFN EVRGSNMSCT PQFITTAPCS PEIKNVSRDA FSMINVHWRS
   481  TNDDATYTVT AQGEKGLYQC SSTGESCTMR GLPCGSVFSV TAVAETQAGR SLPSYSVPLE
   541  TVPCCPTGLT VTQITQSVIN VSWTIGRVAQ THVAVLESHT GQSKCHTHQN HCLLGCITCG
   601  INYTVTLKAI SATGLTADCS YQSYFSGACC PLGVKLYRLG PNGIRIYWQA SRGSANYSTD
   661  LYGSKGIFTC TPSAGLSFCD VTEIPCGDVY TVMVSPVAKT GLKLTFCPKK IYSVTCSGST
   721  LGMVIYRGKR NEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNDC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

testis: 1 nTPM
hippocampal formation: 0.4 nTPM
retina: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
hypothalamus: 0.2 nTPM

Single-cell type

ependymal cells: 39 nCPM
astrocytes: 8.5 nCPM
bergmann glia: 8.5 nCPM
oligodendrocyte progenitor cells: 6.5 nCPM
sertoli cells: 5.6 nCPM
pituitary stem cells: 5.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 3 nTPM
medulla oblongata: 2.6 nTPM
cerebral cortex: 1.8 nTPM
spinal cord: 1.6 nTPM
white matter: 1.3 nTPM
basal ganglia: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNDC7 as an antibody target. Whether an autoantibody or antibody against FNDC7 could matter depends on whether native FNDC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNDC7 is annotated as secreted, so native FNDC7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FNDC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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