FNDC5
Fibronectin type III domain-containing protein 5
Also known as: FNDC5_HUMAN, FRCP2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NAU1
- Gene
- FNDC5
- Ensembl
- ENSG00000160097
- Chromosome
- 1
- Canonical length
- 260 aa
- Protein class
- Predicted membrane proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Canonical amino-acid sequenceUniProt
260 residues, UniProt reviewed canonical sequence.
>Q8NAU1|FNDC5
1 MQAARGGAGR PERPGRPGRG PERERERPPG AGAASPCAAP GLPAGGATIH PGSPSAWPPR
61 ARAALRLWLG CVCFALVQAD SPSAPVNVTV RHLKANSAVV SWDVLEDEVV IGFAISQQKK
121 DVRMLRFIQE VNTTTRSCAL WDLEEDTEYI VHVQAISIQG QSPASEPVLF KTPREAEKMA
181 SKNKDEVTMK EMGRNQQLRT GEVLIIVVVL FMWAGVIALF CRQYDIIKDN EPNNNKEKTK
241 SASETSTPEH QGGGLLRSKILocalizationUniProt · AlphaFold · HPA
Whether an antibody against FNDC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 446 nTPM
Expression across tissuesHPA
Tissue
- tongue: 446 nTPM
- skeletal muscle: 303 nTPM
- cerebellum: 49 nTPM
- choroid plexus: 45 nTPM
- heart muscle: 40 nTPM
- salivary gland: 24 nTPM
Single-cell type
- retinal amacrine cells: 45 nCPM
- retinal pigment epithelial cells: 43 nCPM
- adrenal medulla cells: 43 nCPM
- retinal bipolar cells: 41 nCPM
- choroid plexus epithelial cells: 39 nCPM
- myonuclei: 37 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 115 nTPM
- thalamus: 76 nTPM
- cerebellum: 58 nTPM
- hypothalamus: 49 nTPM
- midbrain: 44 nTPM
- medulla oblongata: 36 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.73
- gnomAD pLI
- 0.55
- gnomAD missense Z
- 0.6
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FNDC5 as an antibody target. Whether an autoantibody or antibody against FNDC5 could matter depends on whether native FNDC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FNDC5 is annotated at the cell surface, where native FNDC5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label FNDC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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